morphoМорфологические ведомостиMorphological newsletter1812-31712686-8741Private Medical University REAVIZ10.20340/mv-mn.18(26).02.41-44morpho-119Research ArticleКРАТКИЕ СООБЩЕНИЯSHORT ARTICLESМОРФОЛОГИЯ ПЕЧЕНИ КРЫС ПРИ ДЛИТЕЛЬНОМ КОРМЛЕНИИ НЕЗДОРОВОЙ ПИЩЕЙTHE RAT’S LIVER MORPHOLOGY AT LONGEST FEEDING WITH JUNK FOODКондашевскаяМ. В.KondashevskayaM. V.histologist77@mail.ruАлексееваА. И.AlekseevaA. I.mariott@bk.ruЧернышеваМ. Б.ChernyshevaM. B.m.b.chern@gmail.comНаучно-исследовательский институт морфологии человекаРоссияResearch Institute of Human MorphologyRussian Federation2018300620182624144Copyright © Кондашевская М.В., Алексеева А.И., Чернышева М.Б., 20182018Кондашевская М.В., Алексеева А.И., Чернышева М.Б.Kondashevskaya M.V., Alekseeva A.I., Chernysheva M.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.morpholetter.com/jour/article/view/119

Проведено исследование влияния регулярного употребления нездоровой пищи - «джанк-фуд» (junk-food) на морфофункциональное состояние печени половозрелых самок крыс Вистар. Животные опытных групп в течение 100 дней получали рацион, включающий картофельные чипсы и сладкие кофеиносодержащие безалкогольные газированные напитки. В печени крыс опытных групп выявлены дистрофические изменения гепатоцитов - мелкая, средняя и крупнокапельная вакуольная дистрофия от степени слабой до выраженной. По сравнению с контрольной группой у крыс, потреблявших «джанк-фуд», отмечено уменьшение объема гепатоцитов, их ядер и содержания гликогена. Выявленные изменения отражают нарушения метаболического баланса печени и свидетельствует о развитии функциональных изменений, обеспечивающих углеводно-жировой, водно-электролитный и белковый обмен.

The effect of the regular use of junk-food on the morphological and functional state of the liver was studied in mature females Wistar rats. Animals of experimental groups received for a 100 days a diet that included potato chips and sweet caffeine-containing soft drinks. In the liver of rats of experimental groups dystrophic changes in hepatocytes - small-, medium- and large-droplet vacuolar dystrophy from weak to severe, were detected. Compared to the control group, rats, which consumed junk-food, had a decrease in the cell and nuclei volume and glycogen content of hepatocytes. Revealed changes reflect alteration of the liver metabolic balance and point to the development of functional changes, that provide carbohydrate-fat, water-electrolyte and protein metabolism.

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The authors declare that there are no conflicts of interest present.