morphoМорфологические ведомостиMorphological newsletter1812-31712686-8741Private Medical University REAVIZ10.20340/mv-mn.18(26).04.32-34morpho-146Research ArticleКРАТКИЕ СООБЩЕНИЯSHORT ARTICLESМОРФОФУНКЦИОНАЛЬНАЯ ХАРАКТЕРИСТИКА ЯИЧЕК БЕЛЫХ КРЫС ПРИ ВОЗДЕЙСТВИИ БИСФЕНОЛА А И ТРИКЛОЗАНАMORPHOFUNCTIONAL CHARACTERISTICS OF TESTES IN WHITE RATS TREATED WITH BISPHENOL A AND TRICLOSANЧигринецС. В.ChigrinetsS. V.chigrinstas@gmail.comБрюхинГ. В.BryuhinG. V.bgenvas@mail.ruЗавьяловС. Н.ZavyalovS. N.chigrinstas@gmail.comЮжно-Уральский государственный медицинский университетРоссияSouth Ural State Medical UniversityRussian Federation2018301220182643234Copyright © Чигринец С.В., Брюхин Г.В., Завьялов С.Н., 20182018Чигринец С.В., Брюхин Г.В., Завьялов С.Н.Chigrinets S.V., Bryuhin G.V., Zavyalov S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.morpholetter.com/jour/article/view/146

Изучали влияние нестойких убиквитарных эндокринных дизрапторов бисфенола A (ВРА) и триклозана (TCS) на репродуктивную функцию половозрелых самцов крыс Вистар. Концентрации ВРА и TCS измеряли непосредственно в ткани яичка методом газовой хроматографии с масс-спектрометрией (GC-MS). Было обнаружено, что группы сравнения статистически значимо различались по концентрации бисфенола А и триклозана в тканях яичка. Проведенное исследование показало, что бисфенол А и триклозан оказывают негативное влияние на морфофункциональное состояние мужских половых желез половозрелых крыс, вызывая снижение массы яичек, уменьшение площади паренхимы, числа и диаметра семенных извитых канальцев, увеличение числа извитых семенных канальцев со слущенным эпителием, а также снижение количества сперматозоидов на фоне увеличения их атипичных форм.

We studied the effect of unstable ubiquitous endocrine disrupters bisphenol A (BPA) and triclosan (TCS) on the reproductive function of adult male Wistar rats. BPA and TCS concentrations were measured directly in testicular tissue by gas chromatography with mass spectrometry (GC-MS). Comparison groups were found to be statistically significantly different in the concentrations of bisphenol A and triclosan in testicular tissues. The study showed that bisphenol A and triclosan have a negative effect on the morphofunctional state of the male reproductive glands of sexually mature rats, causing a decrease in testicular mass, a decrease in parenchyma, the number and diameter of the seminiferous tubules, an increase in the number of convoluted seminiferous tubules with desquamated epithelium, and a decrease in sperm cells on the background of an increase in their atypical forms.

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The authors declare that there are no conflicts of interest present.