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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">morpho</journal-id><journal-title-group><journal-title xml:lang="ru">Морфологические ведомости</journal-title><trans-title-group xml:lang="en"><trans-title>Morphological newsletter</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1812-3171</issn><issn pub-type="epub">2686-8741</issn><publisher><publisher-name>Private Medical University REAVIZ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/mv-mn.2015.0(1):11-17</article-id><article-id custom-type="elpub" pub-id-type="custom">morpho-233</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH ARTICLES</subject></subj-group></article-categories><title-group><article-title>УЛЬТРАСТРУКТУРНЫЕ ИЗМЕНЕНИЯ КЛЕТОК СЛИЗИСТОЙ ОБОЛОЧКИ ЖЕЛУДКА ПРИ БРОНХИАЛЬНОЙ АСТМЕ</article-title><trans-title-group xml:lang="en"><trans-title>ULTRASTRUCTURAL CHANGES OF CELLS OF THE GASTRIC MUCOSA AT ASTHMA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бархина</surname><given-names>Татьяна Григорьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Barkhina</surname><given-names>T. G.</given-names></name></name-alternatives><email xlink:type="simple">tbarkhina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михалева</surname><given-names>Людмила Михайловна</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhaleva</surname><given-names>L. M.</given-names></name></name-alternatives><email xlink:type="simple">mikhalevalm@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голованова</surname><given-names>Валентина Евгеньевна</given-names></name><name name-style="western" xml:lang="en"><surname>Golovanova</surname><given-names>V. E.</given-names></name></name-alternatives><email xlink:type="simple">golovanova-v-e@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гущин</surname><given-names>Михаил Юрьевич</given-names></name><name name-style="western" xml:lang="en"><surname>Gushchin</surname><given-names>M. Yu.</given-names></name></name-alternatives><email xlink:type="simple">guschin.michail@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черников</surname><given-names>Валерий Петрович</given-names></name><name name-style="western" xml:lang="en"><surname>Chernikov</surname><given-names>V. P.</given-names></name></name-alternatives><email xlink:type="simple">tbarkhina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ «Научно-исследовательский институт морфологии человека» РАН</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>2015</year></pub-date><volume>23</volume><issue>1</issue><fpage>11</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бархина Т.Г., Михалева Л.М., Голованова В.Е., Гущин М.Ю., Черников В.П., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Бархина Т.Г., Михалева Л.М., Голованова В.Е., Гущин М.Ю., Черников В.П.</copyright-holder><copyright-holder xml:lang="en">Barkhina T.G., Mikhaleva L.M., Golovanova V.E., Gushchin M.Y., Chernikov V.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.morpholetter.com/jour/article/view/233">https://www.morpholetter.com/jour/article/view/233</self-uri><abstract><p>Бронхиальная астма является многофункциональной патологией, в основе которой лежат клеточно-гуморальные механизмы развития повреждений различных органов и тканей. Наиболее часто вовлекаются в этот патологический процесс органы пищеварительной системы. Цель исследования - изучение ультраструктурных особенностей клеток слизистой оболочки желудка как центрального органа пищеварения и имеющего большее количество различных популяций клеток, участвующих в разных его функциях, при бронхиальной астме различной степени тяжести. Материалом для исследования послужили биоптаты желудка 19 пациентов с контролируемой бронхиальной астмой легкой степени тяжести, 15 пациентов с бронхиальной астмой средней степени тяжести и 12 пациентов с тяжелой степенью. Полутонкие срезы изучали на световом бинокулярном микроскопе с цифровым анализатором, ультратонкие срезы исследовали на трансмиссионном электронном микроскопе. В статье представлены результаты исследования ультраструктурных нарушений клеток желудка при бронхиальной астме. Авторами установлено, что при разной степени тяжести бронхиальной астмы наблюдаются характерные для каждой группы нарушения в эпителиальных, секреторных клетках, и клетках собственной пластинки слизистой оболочки. Выявлено, что комплексная базисная терапия бронхиальной астмы средней степени тяжести оказывает мембран-стабилизирующее воздействие на клетки слизистой оболочки, но во всех группах прослеживаются ультраструктурные изменения органелл, как в проксимальных, так и в дистальных отделах желудка. Представлены некоторые ультраструктурные доказательства процессов клеточно-тканевого ремоделирования разных отделов желудка при бронхиальной астме.</p></abstract><trans-abstract xml:lang="en"><p>The asthma is a multi-functional pathology, which is based on cellular and humoral mechanisms of the damage to various organs and tissues. Most often the digestive system is involved in this pathological process. The aim of the research was investigate ultra-structural features of cells of the gastric mucosa as the central organ in the digestive and having more different populations of cells involved in different functions in the asthma of varying severity. The material for the study was the biopsy specimens of the stomach from 19 patients with controlled asthma mild, from 15 patients with bronchial asthma of moderate severity and from 12 patients with a severe degree. Semi-thin sections were examined on a optic binocular microscope with the digital analyzer; ultra-thin sections were examined on a transmission electron microscope. The article present results of ultra-structural studies of disorders of stomach cells at the bronchial asthma. Authors found that at different severity of asthma observed characteristic for each group of abnormalities in epithelial secretory cells and in cells of the lamina propria of the mucous membranes. It is revealed that integrated basic therapy of bronchial asthma of moderate severity has a membrane-stabilizing effect on the cells of the mucosa, but in all groups can be traced ultra-structural changes of organelles in the proximal and in the distal stomach. In article presents some ultra-structural evidence of the cell-tissues remodeling process in different parts of the stomach in the bronchial asthma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>слизистая оболочка желудка</kwd><kwd>ультраструктурная патология</kwd><kwd>ремоделирование</kwd><kwd>bronchial asthma</kwd><kwd>stomach mucosa cells</kwd><kwd>ultra-structural pathology</kwd><kwd>remodeling</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nemtsov V.I., Aleksandrova R. A., Magidov M.Ya. 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