morphoМорфологические ведомостиMorphological newsletter1812-31712686-8741Private Medical University REAVIZ10.20340/mv-mn.2015.0(1):106-117morpho-249Research ArticleРЕЦЕНЗИИBOOK REVIEWSСОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О СТРУКТУРЕ И ФУНКЦИИ ЭНТЕРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫCURRENT VIEWS ON THE STRUCTURE AND FUNCTION OF ENTERIC NERVOUS SYSTEMХочанскийДмитрий НиколаевичKhochanskijD. N.dimitrvs@mail.ruМакароваОльга ВасильевнаMakarovaO. V.morfolhum@mail.ruФГНБУ «НИИ морфологии человека» РАНRussian FederationМГУ им. М.В. Ломоносова; ФГБУ «НИИ морфологии человека» РАНRussian Federation201530032015231106117Copyright © Хочанский Д.Н., Макарова О.В., 20152015Хочанский Д.Н., Макарова О.В.Khochanskij D.N., Makarova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.morpholetter.com/jour/article/view/249

В обзоре обобщены современные литературные данные о развитии энтеральной нервной системы, строении энтеральных ганглиев и классификации энтеральных нейронов. Охарактеризованы морфологические изменения энтеральной нервной системы при различных заболеваниях.

This overview summarizes the current published data on the development of enteric nervous system, the structure of enteric ganglia and the classification of enteric neurons. The morphological changes of enteric nervous system in various diseases are characterized.

энтеральная нервная системажелудочно-кишечный трактнейробиологияморфологияenteric nervous systemgastrointestinal tractneurobiologymorphologyReferencesНоздрачев А. Д. Физиология вегетативной нервной системы. Л.: Медицина. - 1983. - C. 6.Ноздрачев А. Д. Физиология вегетативной нервной системы. Л.: Медицина. - 1983. - C. 6.Gershon M.D. Development of the enteric nervous system/Gershon MD//Brookes S.J.H., Costa M.(eds) Innervation of the Gastrointestinal Tract. Taylor 8c Francis, London and New York. - 2002. P. 469-525.Gershon M.D. Development of the enteric nervous system/Gershon MD//Brookes S.J.H., Costa M.(eds) Innervation of the Gastrointestinal Tract. Taylor 8c Francis, London and New York. - 2002. P. 469-525.Young H.M. A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture/Hearn C.J., Ciampoli D., Southwell B.R., Brunet J.F., Newgreen D.F. //Dev. Biol. - 1998. - V. 202. - P. 67-84.Young H.M. A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture/Hearn C.J., Ciampoli D., Southwell B.R., Brunet J.F., Newgreen D.F. //Dev. Biol. - 1998. - V. 202. - P. 67-84.Kapur R.P. Colonization of the murine hindgut by sacral crest-derived neural precursors: experimental support for an evolutionarily conserved model/ Kapur R.P. //Dev. Biol. - 2000. - V. 227. - P. 146-155.Kapur R.P. Colonization of the murine hindgut by sacral crest-derived neural precursors: experimental support for an evolutionarily conserved model/ Kapur R.P. //Dev. Biol. - 2000. - V. 227. - P. 146-155.Wallace A.S. Development of the enteric nervous system, smooth muscle and interstitial cells of Cajal in the human gastrointestinal tract / Wallace A.S., Burns A.J. // Cell Tissue Res. - 2005. - V. 319. - P. 367-382.Wallace A.S. Development of the enteric nervous system, smooth muscle and interstitial cells of Cajal in the human gastrointestinal tract / Wallace A.S., Burns A.J. // Cell Tissue Res. - 2005. - V. 319. - P. 367-382.Jiang Y. Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas / Jiang Y., Liu M.T., Gershon M.D. //Dev. Biol. - 2003. - V. 258. - P. 364-384.Jiang Y. Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas / Jiang Y., Liu M.T., Gershon M.D. //Dev. Biol. - 2003. - V. 258. - P. 364-384.Newgreen D. Enteric nervous system: development and developmental disturbances - Part 1 /Newgreen D., Young H.M. //Pediatr. Develop. Pathol. - 2002. - V. 5. - P. 224-247.Newgreen D. Enteric nervous system: development and developmental disturbances - Part 1 /Newgreen D., Young H.M. //Pediatr. Develop. Pathol. - 2002. - V. 5. - P. 224-247.Furness J.B. The enteric nervous system and neurogastroenterology./ Furness J.B. // Nature Reviews Gastroenterology and Hepatology. - 2012. - № 9. - P. 286-294.Furness J.B. The enteric nervous system and neurogastroenterology./ Furness J.B. // Nature Reviews Gastroenterology and Hepatology. - 2012. - № 9. - P. 286-294.Furness, J. B. The Enteric Nervous System. Publisher: Blackwell, Oxford. - 2006.Furness, J. B. The Enteric Nervous System. Publisher: Blackwell, Oxford. - 2006.Li P.L. The intramural nervous system of the small intestine with special reference to the innervation of the inner subdivision of its circular muscle / Li P.L. // Anat. - 1940. - V. 74. - P. 348-359.Li P.L. The intramural nervous system of the small intestine with special reference to the innervation of the inner subdivision of its circular muscle / Li P.L. // Anat. - 1940. - V. 74. - P. 348-359.Timmermans J.P. Outer submucous plexus: an intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans.Anat / Timmermans J.P., Hens J., Adriaensen D. //Rec. - 2001. - V.262. - P. 71-78.Timmermans J.P. Outer submucous plexus: an intrinsic nerve network involved in both secretory and motility processes in the intestine of large mammals and humans.Anat / Timmermans J.P., Hens J., Adriaensen D. //Rec. - 2001. - V.262. - P. 71-78.Timmermans J.P. Structural organization and neuropeptide distribution in the mammalian enteric nervous system, with special attention to those components involved in mucosal reflexes / Timmermans J.P., Adriaensen D., Cornelissen W., Scheuermann D.W. // Comp. Biochem. Physiol. - 1997. - V. 118a. - P. 331-340.Timmermans J.P. Structural organization and neuropeptide distribution in the mammalian enteric nervous system, with special attention to those components involved in mucosal reflexes / Timmermans J.P., Adriaensen D., Cornelissen W., Scheuermann D.W. // Comp. Biochem. Physiol. - 1997. - V. 118a. - P. 331-340.Schofield G.C. // Handbook of Physiology: Alimentary Canal. American Physiological Society, Washington, DC. - 1968. - Vol. 46. - P. 1579-1627.Schofield G.C. // Handbook of Physiology: Alimentary Canal. American Physiological Society, Washington, DC. - 1968. - Vol. 46. - P. 1579-1627.Izumi N. Morphological and morphometrical characteristics of the esophageal intrinsic nervous system in the golden hamster/Izumi N., Matsuyama H., Yamamoto Y., Atoji Y., Suzuki Y., Unno T., Takewaki T. // Eur. J. Morphol. - 2002. - V.40. - P. 137-144.Izumi N. Morphological and morphometrical characteristics of the esophageal intrinsic nervous system in the golden hamster/Izumi N., Matsuyama H., Yamamoto Y., Atoji Y., Suzuki Y., Unno T., Takewaki T. // Eur. J. Morphol. - 2002. - V.40. - P. 137-144.Balemba O.B. The19. Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum organisation of the enteric nervous system in the submucous and mucous layers of the small intestine of the pig studied by VIP and neurofilament protein immunohistochemistry / Balemba O.B., Grondahl M.L., Mbassa G.K., Semuguruka W.D., Hay Smith A. // J. Anat. - 1998. - V. 192. - P. 257-267.Balemba O.B. The19. Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum organisation of the enteric nervous system in the submucous and mucous layers of the small intestine of the pig studied by VIP and neurofilament protein immunohistochemistry / Balemba O.B., Grondahl M.L., Mbassa G.K., Semuguruka W.D., Hay Smith A. // J. Anat. - 1998. - V. 192. - P. 257-267.Mawe G.M., Relationship of gallbladder ganglia to the enteric nervous system: structure, putative neurotransmitters and direct neural connections / Mawe G.M., Gershon M.D. //Singer M.V., Goebell H. (eds) Nerves and the Gastrointestinal Tract. Kluwer Academic Publishers, The Netherlands. -1989. - P. 87-96.Mawe G.M., Relationship of gallbladder ganglia to the enteric nervous system: structure, putative neurotransmitters and direct neural connections / Mawe G.M., Gershon M.D. //Singer M.V., Goebell H. (eds) Nerves and the Gastrointestinal Tract. Kluwer Academic Publishers, The Netherlands. -1989. - P. 87-96.Watari N. Fine structure of nervous elements in the pancreas of some vertebrates / Watari N. //Z. Zellforsch. - 1968. - V. 85. - P. 291-314.Watari N. Fine structure of nervous elements in the pancreas of some vertebrates / Watari N. //Z. Zellforsch. - 1968. - V. 85. - P. 291-314.Furness J.B. Types of nerves in the enteric nervous system / Furness J.B., Costa M. // Neuroscience. -1980. - V. 5. - P. 1-20.Furness J.B. Types of nerves in the enteric nervous system / Furness J.B., Costa M. // Neuroscience. -1980. - V. 5. - P. 1-20.Komuro T. An ultrastructural study of neurons and non-neuronal cells in the myenteric plexus of the rabbit colon/Komuro T., Bałuk P., Burnstock G. //Neuroscience. - 1982. - V. 7(7). - P. 1797-1806.Komuro T. An ultrastructural study of neurons and non-neuronal cells in the myenteric plexus of the rabbit colon/Komuro T., Bałuk P., Burnstock G. //Neuroscience. - 1982. - V. 7(7). - P. 1797-1806.Gabella G. On the ultrastructure of the enteric nerve ganglia/Gabella G. //Scand. J. Gastroenterol. Suppl. - 1982. - V.71. - P. 15-25.Gabella G. On the ultrastructure of the enteric nerve ganglia/Gabella G. //Scand. J. Gastroenterol. Suppl. - 1982. - V.71. - P. 15-25.Wood J. D. Enteric Nervous System (The Brain-In-The-Gut) Publisher: Morgan and Claypool Life Science. - 2011.Wood J. D. Enteric Nervous System (The Brain-In-The-Gut) Publisher: Morgan and Claypool Life Science. - 2011.Хауликэ И. Вегетативная нервная система -Анатомия и физиология- Медицинское издательство бухарест. - 1978. - C. 54-56.Хауликэ И. Вегетативная нервная система -Анатомия и физиология- Медицинское издательство бухарест. - 1978. - C. 54-56.Stach W. Structural organization of enteric nerve cells in large mammals including man / Stach W., Krammer H.J, Brehmer A. // Krammer H.J., Singer M.V.(eds) Neurogastroenterology from the Basics to the Clinics. Publisher: Kluwer Academic Publishers, Dordrecht, The Netherlands. - 2000. - P. 3-20.Stach W. Structural organization of enteric nerve cells in large mammals including man / Stach W., Krammer H.J, Brehmer A. // Krammer H.J., Singer M.V.(eds) Neurogastroenterology from the Basics to the Clinics. Publisher: Kluwer Academic Publishers, Dordrecht, The Netherlands. - 2000. - P. 3-20.Brehmer A., Immunohistochemical characterization of putative primary afferent (sensory) myenteric neurons in human small intestine / Brehmer A., Croner R., Dimmler A., Papadopoulos T., Schrodl F., Neuhuber W. //Autonom. Neurosci. - 2004. - V. 112. - P. 49 59.Brehmer A., Immunohistochemical characterization of putative primary afferent (sensory) myenteric neurons in human small intestine / Brehmer A., Croner R., Dimmler A., Papadopoulos T., Schrodl F., Neuhuber W. //Autonom. Neurosci. - 2004. - V. 112. - P. 49 59.Pompolo S. Ultrastructure and synaptic relationships of calbindin-reactive, Dogiel type II neurons, in myenteric ganglia of guinea-pig small intestine/Pompolo S., Furness J.B. //Neurocytol. - 1988. - V. 17. - P. 771-782.Pompolo S. Ultrastructure and synaptic relationships of calbindin-reactive, Dogiel type II neurons, in myenteric ganglia of guinea-pig small intestine/Pompolo S., Furness J.B. //Neurocytol. - 1988. - V. 17. - P. 771-782.Wang F. B. Topographic inventories of vagal afferents in gastrointestinal muscle / Wang F.B., Powley T.L. // Comp. Neurol. - 2000. - V. 421. - P. 302-324.Wang F. B. Topographic inventories of vagal afferents in gastrointestinal muscle / Wang F.B., Powley T.L. // Comp. Neurol. - 2000. - V. 421. - P. 302-324.Ward S.M. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons / Ward S.M., Beckett E.A.H., Wang X.Y., Baker F., Khoyi M., Sanders K.M.// Neurosci. - 2000. - V. 20. - P. 1393-1403.Ward S.M. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons / Ward S.M., Beckett E.A.H., Wang X.Y., Baker F., Khoyi M., Sanders K.M.// Neurosci. - 2000. - V. 20. - P. 1393-1403.Genton L., Interactions between the enteric nervous system and the immune system: role of neuropeptides and nutrition/Genton L., Kudsk K.A. //Am J Surg. - 2003. - V.186(3). - P. 253-258.Genton L., Interactions between the enteric nervous system and the immune system: role of neuropeptides and nutrition/Genton L., Kudsk K.A. //Am J Surg. - 2003. - V.186(3). - P. 253-258.Muller P. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility/Muller P., Koscso B., Rajani G., Stevanovic K., Berres M., Hashimoto D., Mortha A., Leboeuf M., Li X., Mucida D., Stanley E., Dahan S., Margolis K., Gershon M., Merad M1., Bogunovic M. // Cell. 2014 Jul 17;158(2):300-13Muller P. Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility/Muller P., Koscso B., Rajani G., Stevanovic K., Berres M., Hashimoto D., Mortha A., Leboeuf M., Li X., Mucida D., Stanley E., Dahan S., Margolis K., Gershon M., Merad M1., Bogunovic M. // Cell. 2014 Jul 17;158(2):300-13Furness J.B. Intrinsic primary afferent neurons of the intestine/Furness J.B., Kunze W.A., Bertrand P. P., Clerc N., Bornstein J.C.//Prog. Neurobiol. - 1998. -V. 54(1). - P. 1-18.Furness J.B. Intrinsic primary afferent neurons of the intestine/Furness J.B., Kunze W.A., Bertrand P. P., Clerc N., Bornstein J.C.//Prog. Neurobiol. - 1998. -V. 54(1). - P. 1-18.Kunze W.A.A, The soma and neurites of primary afferent neurons in the guinea-pig intestine respond differentially to deformation / Kunze W.A.A., Clerc N., Furness J.B., Gola M. // Physiol. (Lond.). - 2000. - V. 526. - P. 375-385.Kunze W.A.A, The soma and neurites of primary afferent neurons in the guinea-pig intestine respond differentially to deformation / Kunze W.A.A., Clerc N., Furness J.B., Gola M. // Physiol. (Lond.). - 2000. - V. 526. - P. 375-385.Furness J.B. Nutrient tasting and signaling mechanisms in the gut II. The intestine as a sensory organ: neural, endocrine, and immune responses / Furness J.B., Kunze W.A.A., Clerc N.//Am. J. Physiol. - 1999. - V. 277. - P. G922-G928.Furness J.B. Nutrient tasting and signaling mechanisms in the gut II. The intestine as a sensory organ: neural, endocrine, and immune responses / Furness J.B., Kunze W.A.A., Clerc N.//Am. J. Physiol. - 1999. - V. 277. - P. G922-G928.Kunze W.A.A. The enteric nervous system and regulation of intestinal motility /Kunze W.A.A., Furness J.B. //Annu. Rev. Physiol. - 1999. - V. 61. - P. 117-142.Kunze W.A.A. The enteric nervous system and regulation of intestinal motility /Kunze W.A.A., Furness J.B. //Annu. Rev. Physiol. - 1999. - V. 61. - P. 117-142.Szurszewski J.H. Physiology of prevertebral ganglia / Szurszewski J.H., Miller S.M. // Johnson LR (ed.) Physiology of the Gastrointestinal Tract. Publisher: Raven Press, New York. - 1994. - P. 795-877.Szurszewski J.H. Physiology of prevertebral ganglia / Szurszewski J.H., Miller S.M. // Johnson LR (ed.) Physiology of the Gastrointestinal Tract. Publisher: Raven Press, New York. - 1994. - P. 795-877.Smith T.K., Recent advances in enteric neurobiology: mechanosensitive interneurons / Spencer N.J, Hennig G.W., Dickson E.J. // Neurogastroenterol Motil. - 2007. - V. 19(11). - P. 869-78.Smith T.K., Recent advances in enteric neurobiology: mechanosensitive interneurons / Spencer N.J, Hennig G.W., Dickson E.J. // Neurogastroenterol Motil. - 2007. - V. 19(11). - P. 869-78.Renzi D. Substance P (neurokinin- 1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine/Renzi D., Pellegrini B., Tonelli F., Surrenti C., Calabro A. //Am. J. Pathol. - 2000. - V.157 - P. 1511-1522.Renzi D. Substance P (neurokinin- 1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine/Renzi D., Pellegrini B., Tonelli F., Surrenti C., Calabro A. //Am. J. Pathol. - 2000. - V.157 - P. 1511-1522.Stead R.H. Mast cells are closely apposed to nerves in the human gastrointestinal mucosa/Dixon M.F. Bramwell N.H., Riddell R.H., Bienenstock J. // Gastroenterology. - 1989. - V. 97. - P. 575-585.Stead R.H. Mast cells are closely apposed to nerves in the human gastrointestinal mucosa/Dixon M.F. Bramwell N.H., Riddell R.H., Bienenstock J. // Gastroenterology. - 1989. - V. 97. - P. 575-585.McConalogue K. Gastrointestinal neurotransmitters/ McConalogue K., Furness J.B. //Baillieres Clin Endocrinol Metab. - 1994. - V.8(1). - P. 51-76.McConalogue K. Gastrointestinal neurotransmitters/ McConalogue K., Furness J.B. //Baillieres Clin Endocrinol Metab. - 1994. - V.8(1). - P. 51-76.Kirchgessner A.L. Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos 51. Neural control of the intestinal migrating myoelectric compleximmunoreactivity / Kirchgessner A.L., Tamir H., Gershon M.D. //Neurosci. - 1992. - V.12. - P. 235-248.Kirchgessner A.L. Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos 51. Neural control of the intestinal migrating myoelectric compleximmunoreactivity / Kirchgessner A.L., Tamir H., Gershon M.D. //Neurosci. - 1992. - V.12. - P. 235-248.Pan H. Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine /Pan H., Gershon M.D. //Neurosci. - 2000. - V. 20. - P. 3295-330Pan H. Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine /Pan H., Gershon M.D. //Neurosci. - 2000. - V. 20. - P. 3295-330Zagorodnyuk V. Pharmacological evidence for the existence of multiple P2 receptors in the circular mus21. system in the golden hamster cle of guinea-pig colon. /Zagorodnyuk V., Maggi C.A. // Br. J. Pharmacol. -1998. - V.123. - P. 122-128.Zagorodnyuk V. Pharmacological evidence for the existence of multiple P2 receptors in the circular mus21. system in the golden hamster cle of guinea-pig colon. /Zagorodnyuk V., Maggi C.A. // Br. J. Pharmacol. -1998. - V.123. - P. 122-128.Rand M.J. Nitrergic transmission: Nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission / Rand M.J. // Clin. Exp. Pharmacol. Physiol. - 1992. - V. 19. - P. 147-169.Rand M.J. Nitrergic transmission: Nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission / Rand M.J. // Clin. Exp. Pharmacol. Physiol. - 1992. - V. 19. - P. 147-169.Makhlouf G. M. Nonadrenergic noncholingeric inhibitory transmitters of the gut./ Makhlouf G.M., Grider J.R. // News Physiol. Sci. - 1993. - V.8. - P. 196-199.Makhlouf G. M. Nonadrenergic noncholingeric inhibitory transmitters of the gut./ Makhlouf G.M., Grider J.R. // News Physiol. Sci. - 1993. - V.8. - P. 196-199.Xue L. Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes / Farrugia G., Miller S. M., Ferris C. D., Snyder S.H., Szurszewski J.H. // Proc Natl Acad Sci U S A. - 2000. - V. 97. - P. 1851-1855.Xue L. Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes / Farrugia G., Miller S. M., Ferris C. D., Snyder S.H., Szurszewski J.H. // Proc Natl Acad Sci U S A. - 2000. - V. 97. - P. 1851-1855.Schubert M.L. Regulation of gastrin and somatostatin secretion by intramural neurons: effect of nicotinic receptor stimulation with dimethyl-phenylpiperazinium/Schubert M.L., Makhlouf G.M. //Gastroenterology. - 1982. - V. 83. - P. 626-632.Schubert M.L. Regulation of gastrin and somatostatin secretion by intramural neurons: effect of nicotinic receptor stimulation with dimethyl-phenylpiperazinium/Schubert M.L., Makhlouf G.M. //Gastroenterology. - 1982. - V. 83. - P. 626-632.Liddle R. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 9th ed. /Feldman M., Friedman L.S. Brandt L.J. Saunders. - 2010. - P. 3-20.Liddle R. Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 9th ed. /Feldman M., Friedman L.S. Brandt L.J. Saunders. - 2010. - P. 3-20.Horiguchi K. Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum./HoriguchiK., Semple G.S.A., Sanders K.M., Ward S.M. //Physiol. (Lond.). - 2001. - V.537.1. - P. 237-250.Horiguchi K. Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum./HoriguchiK., Semple G.S.A., Sanders K.M., Ward S.M. //Physiol. (Lond.). - 2001. - V.537.1. - P. 237-250.Morgan K.G. Intracellular electrical activity of musclaris mucosae of the dog stomach / Morgan K.G., Angel F., Schmalz P.F. //Am. Physiol. - 1985. - V. 249. - P. G256-G263.Morgan K.G. Intracellular electrical activity of musclaris mucosae of the dog stomach / Morgan K.G., Angel F., Schmalz P.F. //Am. Physiol. - 1985. - V. 249. - P. G256-G263.Szurszewski J.H. A migrating electric complex of the canine small intestine /Szurszewski J.H. //Am. Physiol. - 1969. - V. 217. - P. 1757-1763.Szurszewski J.H. A migrating electric complex of the canine small intestine /Szurszewski J.H. //Am. Physiol. - 1969. - V. 217. - P. 1757-1763.Carlson G.M. Mechanism of propagation of intestinal interdigestive myoelectric complex / Carlson G.M., Bedi B.S., Code C.F. //Am. J. Physiol. - 1972. - V. 222. - P. 1027-1030.Carlson G.M. Mechanism of propagation of intestinal interdigestive myoelectric complex / Carlson G.M., Bedi B.S., Code C.F. //Am. J. Physiol. - 1972. - V. 222. - P. 1027-1030.Traynor O.J. Canine Interdigestive and postprandial gallbladder motility and emptying / Traynor O.J., Dozois R.R., DiMagno E.P //Am. J. Physiol. - 1984. - V. 246. - P. G426-G432.Traynor O.J. Canine Interdigestive and postprandial gallbladder motility and emptying / Traynor O.J., Dozois R.R., DiMagno E.P //Am. J. Physiol. - 1984. - V. 246. - P. G426-G432.Hasler W.L. Motility of the small intestine and colon/ In: Yamada T. (ed.) Gastroenterology, 2003 vol. 1 p. 220-247. Lippincott Williams & Wilkins, Philadelphia, PA.Hasler W.L. Motility of the small intestine and colon/ In: Yamada T. (ed.) Gastroenterology, 2003 vol. 1 p. 220-247. Lippincott Williams & Wilkins, Philadelphia, PA.Sharkawy T.Y. Neural control of the intestinal migrating myoelectric complex. A pharmacological analysis/El Sharkawy T.Y., Markus H., Diamant N.E. // Can. J. Physiol. Pharmacol. - 1982. - V. 60. - P. 794-804.Sharkawy T.Y. Neural control of the intestinal migrating myoelectric complex. A pharmacological analysis/El Sharkawy T.Y., Markus H., Diamant N.E. // Can. J. Physiol. Pharmacol. - 1982. - V. 60. - P. 794-804.Douglas D.M. Longitudinal and circumferential spread of spike bursts in canine jejunum in vivo / Douglas D.M., Mann F.C., Dusdieker N.S., Summers R. W.//Am. Physiol. - 1980. - V. 239. - P. G311-G318.Douglas D.M. Longitudinal and circumferential spread of spike bursts in canine jejunum in vivo / Douglas D.M., Mann F.C., Dusdieker N.S., Summers R. W.//Am. Physiol. - 1980. - V. 239. - P. G311-G318.Sarna S.K. Giant migrating contractions and their myoelectric correlates in the small intestine //Am. J. Physiol. - 1987. - V. 253. - P. 697-705.Sarna S.K. Giant migrating contractions and their myoelectric correlates in the small intestine //Am. J. Physiol. - 1987. - V. 253. - P. 697-705.Tomaru A. Colonic giant migrating contractions induced by glycerol enema in anesthetized rats / Ishii A., Kishibayashi N., Karasawa A.//JPN. J. Pharmacol. - 1993. - V. 63. - P. 525-528.Tomaru A. Colonic giant migrating contractions induced by glycerol enema in anesthetized rats / Ishii A., Kishibayashi N., Karasawa A.//JPN. J. Pharmacol. - 1993. - V. 63. - P. 525-528.Bassotti G. Colonic motility in ulcerative colitis / Bassotti G.,Antonelli E., Villanacci V.,Baldoni M., Dore M.P.United European // Gastroenterol J. Dec 2014; 2(6): 457-462.Bassotti G. Colonic motility in ulcerative colitis / Bassotti G.,Antonelli E., Villanacci V.,Baldoni M., Dore M.P.United European // Gastroenterol J. Dec 2014; 2(6): 457-462.Jansson G. Hypothalamic control of adrenergic outflow to the stomach in the cat / Jansson G., Lisander B., Martinson J. // Acta Physiol. Scand. -1969. - V. 75. - P. 176-186.Jansson G. Hypothalamic control of adrenergic outflow to the stomach in the cat / Jansson G., Lisander B., Martinson J. // Acta Physiol. Scand. -1969. - V. 75. - P. 176-186.Cirillo C. Ulcerative Colitis - Epidemiology, Pathogenesis and Complications Edited by Mortimer B. O’Connor, Publisher: InTech, Chapters published December 14, - 2011. - P. 29-50. Enteric Nervous System Abnormalities in Ulcerative Colitis By Carla Cirillo, Giovanni Sarnelli and Rosario CuomoCirillo C. Ulcerative Colitis - Epidemiology, Pathogenesis and Complications Edited by Mortimer B. O’Connor, Publisher: InTech, Chapters published December 14, - 2011. - P. 29-50. Enteric Nervous System Abnormalities in Ulcerative Colitis By Carla Cirillo, Giovanni Sarnelli and Rosario CuomoLakhan S.E. Neuroinflammation in inflammatory bowel disease / Lakhan S.E., Kirchgessner A. // J. Neuroinflammation. - 2010. - V.7. - P. 37.Lakhan S.E. Neuroinflammation in inflammatory bowel disease / Lakhan S.E., Kirchgessner A. // J. Neuroinflammation. - 2010. - V.7. - P. 37.Mottet N.K. Histopathologic spectrum of regional enteritis and ulcerative colitis /7. Immunohistochemical localization of the antioxidant enzymes biliverdin reductase and heme oxygenase-2 Mottet N.K. //Major Problems in Pathology. - 1971. - Vol. 2. - P. 1-249.Mottet N.K. Histopathologic spectrum of regional enteritis and ulcerative colitis /7. Immunohistochemical localization of the antioxidant enzymes biliverdin reductase and heme oxygenase-2 Mottet N.K. //Major Problems in Pathology. - 1971. - Vol. 2. - P. 1-249.Rienmann J.F. Ultrastructural changes in the gut autonomic nervous system following laxative abuse and in other conditions / Rienmann J.F., Schmidt H. // Scandinavian Journal of Gastroenterology - 1982. - V. 71. - P. 111-124Rienmann J.F. Ultrastructural changes in the gut autonomic nervous system following laxative abuse and in other conditions / Rienmann J.F., Schmidt H. // Scandinavian Journal of Gastroenterology - 1982. - V. 71. - P. 111-124Lomax A.E. Plasticity of the enteric nervous system during intestinal inflammation./ Lomax A.E., Fernandez, E. & Sharkey, K.A.// Neurogastroenterology and Motilility, Vol. 17, No. 1, 2005, pp. 4-15Lomax A.E. Plasticity of the enteric nervous system during intestinal inflammation./ Lomax A.E., Fernandez, E. & Sharkey, K.A.// Neurogastroenterology and Motilility, Vol. 17, No. 1, 2005, pp. 4-15Linden D.R., Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon / Linden D.R., Couvrette J.M., Ciolino A., McQuoid C., Blaszyk H., Sharkey K.A., Mawe G.M. // Neurogastroenterol. Motil. - 2005. - V.17(5). -P.751-760.Linden D.R., Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon / Linden D.R., Couvrette J.M., Ciolino A., McQuoid C., Blaszyk H., Sharkey K.A., Mawe G.M. // Neurogastroenterol. Motil. - 2005. - V.17(5). -P.751-760.Chandrasekharan B., Srinivasan S. Diabetes and the enteric nervous system / Srinivasan S. // Neurogastroenterol. Motil. - 2007. - № 19(12). - P. 951-60.Chandrasekharan B., Srinivasan S. Diabetes and the enteric nervous system / Srinivasan S. // Neurogastroenterol. Motil. - 2007. - № 19(12). - P. 951-60.

The authors declare that there are no conflicts of interest present.