morphoМорфологические ведомостиMorphological newsletter1812-31712686-8741Private Medical University REAVIZ10.20340/mv-mn.2015.0(2):71-76morpho-262Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯRESEARCH ARTICLESМОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ МИЕНТЕРАЛЬНЫХ ГАНГЛИЕВ ПРИ ЭКСПЕРИМЕНТАЛЬНОМ ОСТРОМ ЯЗВЕННОМ КОЛИТЕMorhological changes of myenteric ganglia in experimental acute ulcerative colitisХочанскийДмитрий НиколаевичKhochanskijD. N.dimitrvs@mail.ruМакароваОльга ВасильевнаMakarovaO. V.morfolhum@mail.ruХудоерковРудольф МихайловичHudoerkovR. M.neurolab@yandex.ruФГБНУ «НИИ морфологии человека»Russian FederationМГУ им. М.В. Ломоносова; ФГБНУ «НИИ морфологии человека»Russian FederationФГБНУ «научный центр неврологии»Russian Federation2015300620152327176Copyright © Хочанский Д.Н., Макарова О.В., Худоерков Р.М., 20152015Хочанский Д.Н., Макарова О.В., Худоерков Р.М.Khochanskij D.N., Makarova O.V., Hudoerkov R.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.morpholetter.com/jour/article/view/262

Проведено морфологическое исследование энтеральной нервной системы ободочной кишки у мышей линии C57Bl/6 при экспериментальном декстраниндуцированном остром язвенном колите. Изучены клеточный состав миентеральных ганглиев и цитометрические показатели миентеральных нейронов. При колите по сравнению с контролем выявлено снижение числа гипохромных нейронов и глиоцитов, увеличение числа гиперхромных нейронов на ганглий, уменьшение размеров нейронов и их ядер. Выявленные морфологические изменения миентеральных ганглиев ободочной кишки при остром язвенном колите могут обусловливать нарушения моторной и секреторной функции.

Myenteric ganglia of colon of C57Bl/6 mice with acute DSS-induced colitis were investigated. The cell composition of myenteric ganglia and cytometric values of myenteric neurons were studied. It was found a decrease in number of hypochromic neurons and glial cells and an increase in number of hyperchromic neurons. The area of neurons and their nuclei decreased in colitis. These morphological changes of myenteric ganglia in colitis may cause an impairing of motor and secretory functions of colon.

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The authors declare that there are no conflicts of interest present.