morphoМорфологические ведомостиMorphological newsletter1812-31712686-8741Private Medical University REAVIZ10.20340/mv-mn.2014.0(3):74-78morpho-336Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯRESEARCH ARTICLESМОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ ВНУТРЕННИХ ОРГАНОВ У КРЫС ПРИ ДЛИТЕЛЬНОМ ИЗБЫТОЧНОМ ПОТРЕБЛЕНИИ УГЛЕВОДОВ И ЖИРОВMORPHOLOGICAL CHANGES OF THE INTERNAL ORGANS OF RATS AFTER LONG-TERM EXCESSIVE CONSUMPTION OF CARBOHYDRATES AND FATSЧернышеваМария БорисовнаChernyshevaM. B.m.b.chern@gmail.comМакароваМария АлександровнаMakarovaM. A.mariya@mai.ruЦветковИван СергеевичTsvetkovI. S.davedm66@gmail.comФГБУ «НИИ морфологии человека» РАНRussian Federation2014300920142237478Copyright © Чернышева М.Б., Макарова М.А., Цветков И.С., 20142014Чернышева М.Б., Макарова М.А., Цветков И.С.Chernysheva M.B., Makarova M.A., Tsvetkov I.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.morpholetter.com/jour/article/view/336

Проведено исследование внутренних органов крыс после длительного (20 недель) избыточного потребления углеводов и жиров. Рацион опытных животных включал обогащенный жиром стандартный корм и 20% раствор фруктозы вместо питьевой воды. Показано, что в отсутствии увеличения массы тела и повышения уровня глюкозы и триглицеридов, у крыс развивается жировая дистрофия печени, липоматоз поджелудочной железы и коронообразные структуры в жировой ткани.

A study of the internal organs of rats after long-term (20 weeks) excessive consumption of carbohydrates and fats was realized. The diet of experimental animals consisted of standard feed, enriched with fat, and 20% fructose solution instead of drinking water. It was shown that in the absence of weight gain and raised glucose and triglyceride levels the rats developed fatty liver disease, lipomatosis of the pancreas and crown-like structures in adipose tissue.

ожирениеметаболический синдромкрысырацион с высоким содержанием жиров и углеводовObesitymetabolic syndromeratshigh-fat and high-fructose dietReferencesAcosta A., Camilleri M. Gastrointestinal Morbidity in Obesity//Acad. Sci. 2014. V.1311. P. 42-56.Acosta A., Camilleri M. Gastrointestinal Morbidity in Obesity//Acad. Sci. 2014. V.1311. P. 42-56.Гинзбург М.М. Ожирение и метаболический синдром. Влияние на состояние здоровья, профилактика и лечение. Самара.: Парус, 2000. 160с.Гинзбург М.М. Ожирение и метаболический синдром. Влияние на состояние здоровья, профилактика и лечение. Самара.: Парус, 2000. 160с.Ройтберг Г.Е. Метаболический синдром. М.: МЕДпресс-информ, 2007. 224 с.Ройтберг Г.Е. Метаболический синдром. М.: МЕДпресс-информ, 2007. 224 с.Струков А.И., Серов В.В. Патологическая анатомия. - М.: Медицина, 1979. 527с.Струков А.И., Серов В.В. Патологическая анатомия. - М.: Медицина, 1979. 527с.Levin B.E., Dunn-Meynell A.A., Balkan B., Keesey R.E. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats //American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 1997. V.273. Р.725-730.Levin B.E., Dunn-Meynell A.A., Balkan B., Keesey R.E. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats //American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 1997. V.273. Р.725-730.Ghibaudi L., Cook J., Farley C., Heek M., Hwa J.J. Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats // Obesity Research. 2002. V.10. N.9.Ghibaudi L., Cook J., Farley C., Heek M., Hwa J.J. Fat Intake Affects Adiposity, Comorbidity Factors, and Energy Metabolism of Sprague-Dawley Rats // Obesity Research. 2002. V.10. N.9.Ricci M.R., Levin B.E. Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats // American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2003. V.285. Р.610-618.Ricci M.R., Levin B.E. Ontogeny of diet-induced obesity in selectively bred Sprague-Dawley rats // American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2003. V.285. Р.610-618.Deng J.Y., Huang J.P., Lu L.S., Hung L.M. Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats// Am J Physiol Heart Circ Physiol. 2007. V. 293(2)Deng J.Y., Huang J.P., Lu L.S., Hung L.M. Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats// Am J Physiol Heart Circ Physiol. 2007. V. 293(2)Axelsen L.N., Lademann J.B., Petersen J.S., Holstein-Rathlou N.H., Ploug T., Prats C., Pedersen H.D., Kjølbye A.L. Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation //Am J Physiol Regul Integr Comp Physiol. 2010. V. 298(6)Axelsen L.N., Lademann J.B., Petersen J.S., Holstein-Rathlou N.H., Ploug T., Prats C., Pedersen H.D., Kjølbye A.L. Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation //Am J Physiol Regul Integr Comp Physiol. 2010. V. 298(6)Angelova P., Boyadjiev N. A review on the models of obesity and metabolic syndrome in rats // Trakia Journal of Sciences. 2013. V. 1. P. 5-12.Angelova P., Boyadjiev N. A review on the models of obesity and metabolic syndrome in rats // Trakia Journal of Sciences. 2013. V. 1. P. 5-12.Grundy S.M., Brewer H.B., Cleeman J.I., Smith S.C., Lenfant C. Definition of Metabolic Syndrome Report of the National Heart, Lung, and Blood Institute // American Heart Association Conference on Scientific Issues Related to Definition Circulation. 2004. V.109. P. 433-438Grundy S.M., Brewer H.B., Cleeman J.I., Smith S.C., Lenfant C. Definition of Metabolic Syndrome Report of the National Heart, Lung, and Blood Institute // American Heart Association Conference on Scientific Issues Related to Definition Circulation. 2004. V.109. P. 433-438Buettner R., Parhofer K., Woenckhaus M., Wrede C., Kunz-Schughart L., Scholmerich J. and Bollheimer L. Defining high-fat-diet rat models: metabolic and molecular effects of different fa t types // Journal of Molecular Endocrinology. 2006. V. 36. P. 485-501.Buettner R., Parhofer K., Woenckhaus M., Wrede C., Kunz-Schughart L., Scholmerich J. and Bollheimer L. Defining high-fat-diet rat models: metabolic and molecular effects of different fa t types // Journal of Molecular Endocrinology. 2006. V. 36. P. 485-501.Selder J., Chen, Y. D., Cully M. and Reaven, G., Hyperinsulinemia in fructose-induced hypertriglyceridemia in rat // Metabolism. 1980. V. 4. P. 303-305.Selder J., Chen, Y. D., Cully M. and Reaven, G., Hyperinsulinemia in fructose-induced hypertriglyceridemia in rat // Metabolism. 1980. V. 4. P. 303-305.

The authors declare that there are no conflicts of interest present.