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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">morpho</journal-id><journal-title-group><journal-title xml:lang="ru">Морфологические ведомости</journal-title><trans-title-group xml:lang="en"><trans-title>Morphological newsletter</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1812-3171</issn><issn pub-type="epub">2686-8741</issn><publisher><publisher-name>Private Medical University REAVIZ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20340/mv-mn.2021.29(1).43-48</article-id><article-id custom-type="elpub" pub-id-type="custom">morpho-453</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH ARTICLES</subject></subj-group></article-categories><title-group><article-title>КОЛИЧЕСТВЕННЫЕ ПАРАМЕТРЫ И МОРФОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА АМПУЛ МАТОЧНЫХ ТРУБ ЖЕНЩИН В ПЕРВОМ ПЕРИОДЕ ЗРЕЛОГО ВОЗРАСТА</article-title><trans-title-group xml:lang="en"><trans-title>QUANTITATIVE PARAMETERS AND MORPHOLOGICAL CHARACTERISTICS OF THE UTERINE TUBES AMPULLAE IN THE FIRST PERIOD OF ADULTHOOD</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Некрасова</surname><given-names>Анна Михайловна</given-names></name><name name-style="western" xml:lang="en"><surname>Nekrasova</surname><given-names>Anna M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры нормальной, топографической и клинической анатомии, оперативной хирургии</p></bio><bio xml:lang="en"><p>Assistant at the Department of Normal, Topographic and Clinical Anatomy, Operative Surgery</p></bio><email xlink:type="simple">anyanekr@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баландина</surname><given-names>Ирина Анатольевна</given-names></name><name name-style="western" xml:lang="en"><surname>Balandina</surname><given-names>Irina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующая кафедрой нормальной, топографической и клинической анатомии, оперативной хирургии</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Head of the Department of Normal, Topographic and Clinical Anatomy, Operative Surgery</p></bio><email xlink:type="simple">balandina_ia@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пермский государственный медицинский университет имени академика Е.А. Вагнера, Пермь</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Academician Vagner Perm State Medical University, Perm</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>30</day><month>05</month><year>2021</year></pub-date><volume>29</volume><issue>1</issue><fpage>43</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Некрасова А.М., Баландина И.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Некрасова А.М., Баландина И.А.</copyright-holder><copyright-holder xml:lang="en">Nekrasova A.M., Balandina I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.morpholetter.com/jour/article/view/453">https://www.morpholetter.com/jour/article/view/453</self-uri><abstract><p>Для определения возрастной анатомической изменчивости нужна его точная морфологическая характеристика в зрелом возрасте, установленная с помощью современных методов исследования, которая может послужить критерием условной нормы. Цель исследования заключается в определении макро- и микро-морфометрических параметров ампул маточных труб женщин в первом периоде зрелого возраста на секционном материале и их морфологической характеристики. Исследовали ампулу обеих маточных труб 44 нерожавших и 58 рожавших женщин первого периода зрелого возраста (от 21 до 35 лет). Применили органометрический, гистологический, иммуногистохимический и макро- и микро-морфометрический методы исследования. Определили длину ампул, их наружный диаметр в месте перехода перешейка в ампулу, в центральной части ампулы и в месте перехода ампулы в воронку. Гистологические срезы окрашивали гематоксилином и эозином, пикрофуксином по ван Гизону. При иммуногистохимическом исследовании образцов использовали антитела на vimentin и маркер CD68. Рассчитывали площадь просвета ампулы маточной трубы, площадь ее стенки и измеряли длину окружности эпителиальной выстилки. В результате установили, что наружный диаметр маточных труб в местах переходов перешейка в ампулу и ампулы в воронку, а также в центральной части ампулы характеризуется отсутствием статистически достоверного различия параметров у нерожавших и рожавших женщин. Гистологическая картина ампул маточных труб как у нерожавших, так и у рожавших женщин в первом периоде зрелого возраста однотипна и представлена слизистой оболочкой, формирующей множество тонких папиллярных складок, внутренним циркулярным и наружным продольным слоями гладкой мышечной ткани мышечной оболочки и серозной оболочкой. Выявление в тканях ампул маточных труб у нерожавших и рожавших женщин в умеренном количестве CD68-иммунопозитивных макрофагов, концентрация которых увеличивается в эпителии и вблизи него, а также экспрессии виментина в стенках сосудов и отдельных фибробластах указывает на наличие процессов физиологической регенерации тканей. Анализ показателей площадей просвета ампулы и ее стенки при срединном сечении, а также длины окружности эпителиальной выстилки позволяет сделать вывод о преобладании этих параметров в правой маточной трубе.</p></abstract><trans-abstract xml:lang="en"><p>The study of the age-related anatomical variability, its exact morphological characteristics in adulthood, established using modern research methods, are needed, which can serve as a criterion for a conditional norm. The aim of the study is to determine the macro- and micro-morphometric parameters of the ampulla of the fallopian tubes of women in the first period of adulthood using prosection material and their morphological characteristics. The ampulla of both fallopian tubes of 44 nulliparous and 58 giving birth women of the first period of adulthood (from 21 to 35 years) were examined. Organometric, histological, immunohistochemical and macro- and micro-morphometric research methods were used. It determined the length of the ampoules, their outer diameter at the junction of the isthmus in the ampoule, in the central part of the ampoule and at the junction of the ampoule in the funnel. Histological sections were stained with hematoxylin and eosin, picro fuchsin according to van Gieson. In the immunohistochemical study of the samples, antibodies against vimentin and the CD68 marker were used. The area of ​​the lumen of the ampulla of the fallopian tube and the area of ​​its wall was calculated, and the circumference of the epithelial lining was measured. As a result, it was found that the outer diameter of the fallopian tubes at the junction of the isthmus into the ampulla and the ampoule into the funnel, as well as in the central part of the ampoule, is characterized by the absence of a statistically significant difference in parameters in nulliparous and giving birth women. The histological picture of the ampulla of the fallopian tubes both in nulliparous and in women giving birth in the first period of adulthood is of the same type and is represented by a mucous membrane that forms many thin papillary folds, internal circular and external longitudinal layers of smooth muscle tissue of the muscular membrane and the serous membrane. The detection in the tissues of the ampulla of the fallopian tubes in nulliparous and giving birth women in a moderate amount of CD68-immunopositive macrophages, the concentration of which increases in the epithelium and near it, as well as the expression of vimentin in the vessel walls and individual fibroblasts, indicates the presence of physiological tissue regeneration processes. Analysis of the indicators of the areas of the lumen of the ampoule and its wall at the median section, as well as the circumference of the epithelial lining, allows us to conclude that these parameters predominate in the right fallopian tube.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ампула маточной трубы</kwd><kwd>морфометрия</kwd><kwd>виментин</kwd><kwd>CD68-позитивные клетки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ampoule of the fallopian tube</kwd><kwd>morphometry</kwd><kwd>vimentin</kwd><kwd>CD68-positive cells</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alekseev UD, Ivahina SA, Efimov AA, Sfvenkova EN, Rajkova KA. Vozrastnye morfologicheskie izmenenija organov zhenskoj polovoj sistemy. Sovremennye problemy nauki i obrazovanija. 2016;4:51.</mixed-citation><mixed-citation xml:lang="en">Alekseev Y.D., Ivahina S.A., Efimov A.A., Savenkova E.N., Raykova K.A. Age-related morphological changes in female reproductive system. Modern problems of science and education. 2016; 4: 51</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Balatsyuk E.V. Morfometricheskaya kharakteristika organov zhenskoy reproduktivnoy sistemy ploda v norme i pri urogenital'nykh infektsiyakh materi.- Avtoref. diss. na soisk. uch. st. kand. med. nauk.- Ul'yanovsk, 2012. 22s.</mixed-citation><mixed-citation xml:lang="en">Aketayeva A.S. Modern view on fallopian tubes anatomy and function. Journal of Clinical Medicine of Kazakhstan. 2016; 2(40): 14-21</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Balatsyuk E.V., Khayrullin R.M., Kan N.I. Organometricheskie osobennosti prenatal'nogo razvitiya vlagalishcha pri normal'noy i oslozhnennoy khronicheskoy urogenital'noy infektsiey materi beremennosti. Morfologicheskie vedomosti. 2012. № 2. S. 92-95.</mixed-citation><mixed-citation xml:lang="en">Pavlov A.V., Korableva T.V., Esev L.I., Fokanova O.A., Lukashevich Yu.A. Methodical approaches to experimental study of histophysiology of mucociliary transport system in the uterine tubes. Morphology. 2019; 155 – 1: 60-65</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Balatsyuk E.V., Khayrullin R.M., Gruzdev S.A. Organometricheskie pokazateli razvitiya yaichnikov u plodov i novorozhdennykh detey pri normal'no protekayushchey beremennosti. V sbornike: Arterial'naya gipertoniya: Retrospektiva i sovremennost'. Problemy vyzhivaemosti v 21 veke. Materialy 47-y mezhregional'noy nauchno-prakticheskoy konferentsii meditsinskikh rabotnikov. Ul'yanovsk: Izd-vo «Artishok», 2012. S. 514-515.</mixed-citation><mixed-citation xml:lang="en">Vafina Z.R., Ziganshina A.U., Fatkullina I.F. Contractile activity of the fallopian tubes and some aspects of its regulation. Kazan medical journal. 2004; 85 – 2: 138-141</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Khayrullin R.M., Balatsyuk E.V. Organometricheskie pokazateli matki plodov i novorozhdennykh detey 22-40 nedel' razvitiya po dannym patomorfologicheskogo issledovaniya. Morfologicheskie vedomosti. 2012. № 1. S. 67-74.</mixed-citation><mixed-citation xml:lang="en">Rodichkina V.R., Kvetnoy I.M., Polyakova V.O. Inflaming is a molecular-cellular mechanism of aging of the female reproductive system. Molecular medicine. 2019; 17-3: 8-14</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Khayrullin R.M., Balatsyuk E.V., Gruzdev S.A., Kan N.I. Prenatal'naya dinamika nekotorykh morfometricheskikh pokazateley organov zhenskoy reproduktivnoy sistemy/ V sbornike: V S"ezd Rossiyskogo obshchestva detskikh patologov. Trudy. S-Pb.: Izd-vo «LEMA», 2012. S. 280-284.</mixed-citation><mixed-citation xml:lang="en">Ezzati M, Djahanbakhch O, Arian S, Carr BR. Tubal transport of gametes and embryos: a review of physiology and pathophysiology. J Assist Reprod Genet. 2014; 31(10):1337-47. DOI: 10.1007/s10815-014-0309-x</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Khayrullin R.M. Prenatal'nyy morfogenez zhenskoy reproduktivnoy sistemy po dannym organometrii. Morfologiya. 2013. T. 144. № 5. S. 124.</mixed-citation><mixed-citation xml:lang="en">Khayrullin R.M. Prenatal'nyy morfogenez zhenskoy reproduktivnoy sistemy po dannym organometrii. Morfologiya. 2013. T. 144. № 5. S. 124.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Balatsyuk E.V., Khayrullin R.M. Malt-struktury organov zhenskoy reproduktivnoy sistemy v prenatal'nom ontogeneze/ V sbornike: Anatomiya cheloveka: vchera, segodnya, zavtra. Materialy konferentsii, posvyashchennoy 250-letiyu kafedry anatomii cheloveka Pervogo MGMU im. I.M. Sechenova (1764-2014). M.: PMGMU, 2014. S. 22-23.</mixed-citation><mixed-citation xml:lang="en">Balatsyuk E.V., Khayrullin R.M. Malt-struktury organov zhenskoy reproduktivnoy sistemy v prenatal'nom ontogeneze/ V sbornike: Anatomiya cheloveka: vchera, segodnya, zavtra. Materialy konferentsii, posvyashchennoy 250-letiyu kafedry anatomii cheloveka Pervogo MGMU im. I.M. Sechenova (1764-2014). M.: PMGMU, 2014. S. 22-23.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Balatsyuk E.V., Khayrullin R.M. Sravnitel'naya kharakteristika gistometricheskikh parametrov vlagalishcha plodov i novorozhdennykh detey 22-40 nedel' razvitiya v norme i pri urogenital'nykh infektsiyakh materi. Meditsinskiy vestnik Bashkortostana. 2014. T. 9. № 5. S. 12-15.</mixed-citation><mixed-citation xml:lang="en">Balatsyuk E.V., Khayrullin R.M. Sravnitel'naya kharakteristika gistometricheskikh parametrov vlagalishcha plodov i novorozhdennykh detey 22-40 nedel' razvitiya v norme i pri urogenital'nykh infektsiyakh materi. Meditsinskiy vestnik Bashkortostana. 2014. T. 9. № 5. S. 12-15.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Krikun E.N., Nikityuk D.B., Klochkova S.V., Khayrullin R.M. Osobennosti fizicheskogo razvitiya novorozhdennykh detey tsentral'no-chernozemnogo rayona Rossii. Voprosy pitaniya. 2014. T. 83. № S3. S. 43.</mixed-citation><mixed-citation xml:lang="en">Krikun E.N., Nikityuk D.B., Klochkova S.V., Khayrullin R.M. Osobennosti fizicheskogo razvitiya novorozhdennykh detey tsentral'no-chernozemnogo rayona Rossii. Voprosy pitaniya. 2014. T. 83. № S3. S. 43.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Tamash YaV, Khayrullin RM, Supilnikov AA, Lysov NA. Variant anatomy of the fallopian tubes and ovaries: side-to-side differences, reference values. Annals of Anatomy. 2021;237(S1):151747.</mixed-citation><mixed-citation xml:lang="en">Tamash YaV, Khayrullin RM, Supilnikov AA, Lysov NA. Variant anatomy of the fallopian tubes and ovaries: side-to-side differences, reference values. Annals of Anatomy. 2021;237(S1):151747.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Aketaeva AS. Sovremennyj vzgljad na anatomiju i funkciju matochnyh trub. Klinicheskaja medicina Kazahstana. 2016;2(40):14-21.</mixed-citation><mixed-citation xml:lang="en">Aketaeva AS. Sovremennyj vzgljad na anatomiju i funkciju matochnyh trub. Klinicheskaja medicina Kazahstana. 2016;2(40):14-21.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pavlov AV, Korableva TV, Esev LI, Fokanova OA, Lukashevich JuA. Metodicheskie podhody k jeksperimental'nomu izucheniju gistofiziologii mukociliarnoj transportnoj sistemy matochnyh trub. Morfologija. 2019;155–1:60-65.</mixed-citation><mixed-citation xml:lang="en">Pavlov AV, Korableva TV, Esev LI, Fokanova OA, Lukashevich JuA. Metodicheskie podhody k jeksperimental'nomu izucheniju gistofiziologii mukociliarnoj transportnoj sistemy matochnyh trub. Morfologija. 2019;155–1:60-65.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Vafina ZR, Ziganshina AU, Fatkullina IF. Sokratitel'naja aktivnost' matochnyh trub i nekotorye aspekty ee reguljacii. Kazanskij medicinskij zhurnal. 2004;85–2:138-141.</mixed-citation><mixed-citation xml:lang="en">Vafina ZR, Ziganshina AU, Fatkullina IF. Sokratitel'naja aktivnost' matochnyh trub i nekotorye aspekty ee reguljacii. Kazanskij medicinskij zhurnal. 2004;85–2:138-141.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rodichkina VR, Kvetnoj IM, Poljakova VO. Inflamaging - molekuljarno-kletochnye mehanizmy starenija zhenskoj reproduktivnoj sistemy. Molekuljarnaja medicina. 2019;17-3:8-14.</mixed-citation><mixed-citation xml:lang="en">Rodichkina VR, Kvetnoj IM, Poljakova VO. Inflamaging - molekuljarno-kletochnye mehanizmy starenija zhenskoj reproduktivnoj sistemy. Molekuljarnaja medicina. 2019;17-3:8-14.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ezzati M, Djahanbakhch O, Arian S, Carr BR. Tubal transport of gametes and embryos: a review of physiology and pathophysiology. J Assist Reprod Genet. 2014;31(10):1337-47. DOI: 10.1007/s10815-014-0309-x.</mixed-citation><mixed-citation xml:lang="en">Ezzati M, Djahanbakhch O, Arian S, Carr BR. Tubal transport of gametes and embryos: a review of physiology and pathophysiology. J Assist Reprod Genet. 2014;31(10):1337-47. DOI: 10.1007/s10815-014-0309-x.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
