morphoМорфологические ведомостиMorphological newsletter1812-31712686-8741Private Medical University REAVIZ10.20340/mv-mn.2025.33(3).929morpho-929Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSПЕРСПЕКТИВЫ ПОВЫШЕНИЯ АДГЕЗИВНОЙ СПОСОБНОСТИ ЭНДОМЕТРИЯ И ЭМБРИОНА ЧЕЛОВЕКА ПРИ ИМПЛАНТАЦИИTHE HUMAN ENDOMETRIUM AND EMBRYO DURING IMPLANTATION ADHESIVE ABILITY ENHANCING PERSPECTIVEShttps://orcid.org/0000-0002-2493-7872ЮхимецСергей НиколаевичYukhimetsSergey N.

кандидат медицинских наук, доцент, доцент кафедры анатомии

Candidate of Medical Sciences, Docent, Associate Professor of the Anatomy Department

sergei.iukhimets@sjchs.sjuit.ac.tzhttps://orcid.org/0000-0002-8681-8844ПоповаОльга ОлеговнаPopovaOl'ga O.

аспирантка кафедры гистологии и эмбриологии

Aspirantin of the Histology and Embryology Department

popovaoo@outlook.comhttps://orcid.org/0000-0002-3903-4350ШурыгинаОксана ВикторовнаShuryginaOksana V.

доктор медицинских наук, доцент, профессор кафедры гистологии и эмбриологии и кафедры репродуктивной медицины, клинической эмбриологии и генетики

Doctor of Medical Sciences, Docent, Professor of the Histology and Embryology and Reproductive Medicine, Clinical Embryology and Genetics Departments

oks-shurygina@yandex.ruhttps://orcid.org/0000-0002-8318-0355КулаковаОлеся ВикторовнаKulakovaOlesya V.

кандидат медицинских наук, доцент, доцент кафедры гистологии и эмбриологии 

Candidate of Medical Sciences, Docent, Associate Professor of the Histology and Embryology Department

olesvk@mail.ruhttps://orcid.org/0000-0002-6610-6807ШурыгинСергей АлександровичShuryginSergey A.

кандидат медицинских наук, ассистент кафедры морфологии и патологии

Candidate of Medical Sciences, Assistant of the Morphology and Pathology Department

sa-shur@yandex.ruРусаковДмитрий ЮрьевичRusakovDmitry Yu.

кандидат медицинских наук, доцент кафедры урологии

Candidate of Medical Sciences, Associate Professor of the Urology Department

maison55@rambler.ruhttps://orcid.org/0000-0003-4920-2511БовтуноваСветлана СергеевнаBovtunovaSvetlana S.

кандидат медицинских наук, доцент, доцент кафедры гистологии и эмбриологии 

Candidate of Medical Sciences, Docent, Associate Professor of the Histology and Embryology Department

s.s.bovtunova@samsmu.ruКорчагинаДина ВикторовнаKorchaginaDina V.

кандидат медицинских наук, доцент кафедры фармакологии имени заслуженного деятеля науки Российской Федерации профессора А.А. Лебедева

Candidate of Medical Sciences, Associate Professor of the Russian Federation Honored Scientist Professor Lebedev Pharmacology Department

d.v.korchagina@samsmu.ruКутихинДмитрий ЮрьевичKutikhinDmitry Yu.

клинический ординатор кафедры неврологии

Clinical Resident of the Neurology Department

lol.gor.2017@mail.ruУниверситет Святого Иосифа в Танзании, Дар-эс-СаламТанзанияSaint Joseph University in Tanzania, Dar es SalaamUnited Republic of TanzaniaСамарский государственный медицинский университет, СамараРоссияSamara State Medical University, SamaraRussian FederationМедицинский университет РЕАВИЗ, СамараРоссияREAVIZ Private Medical University, SamaraRussian Federation202527092025333id-929Copyright © Юхимец С.Н., Попова О.О., Шурыгина О.В., Кулакова О.В., Шурыгин С.А., Русаков Д.Ю., Бовтунова С.С., Корчагина Д.В., Кутихин Д.Ю., 20252025Юхимец С.Н., Попова О.О., Шурыгина О.В., Кулакова О.В., Шурыгин С.А., Русаков Д.Ю., Бовтунова С.С., Корчагина Д.В., Кутихин Д.Ю.Yukhimets S.N., Popova O.O., Shurygina O.V., Kulakova O.V., Shurygin S.A., Rusakov D.Y., Bovtunova S.S., Korchagina D.V., Kutikhin D.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.morpholetter.com/jour/article/view/929

Бесплодие является проблемой глобального масштаба. По данным Всемирной организации здравоохранения за 2023 год бесплодием страдает 17,5 % людей, это каждый шестой человек в мире. По мнению ее экспертов к 2050 году критическое падение рождаемости приведёт к сокращению количества детей до 15 лет на 40% и более. В России статистика отражает общемировые тенденции. В связи с чем поиск новых эффективных способов лечения бесплодия является актуальной задачей современной медицины. Цель обзора состояла в анализе и оценке текущих данных относительно использования среды, обогащенной гиалуроновой кислотой, при переносе эмбрионов для увеличения показателей имплантации в циклах лечения бесплодия методами вспомогательных репродуктивных технологий. Источниками специализированной литературы, использованными в данном обзоре, стали электронные библиотеки научных публикаций и медицинские базы данных, такие как Google Scholar, PubMed и Elibrary.ru. Обзор включал публикации, соответствующие тематике, найденные посредством поиска, по следующим ключевым словам - «вспомогательные репродуктивные технологии», «гиалуроновая кислота», «эмбрион», «эндометрий». В результате исследования выявлено, что Российская Федерация занимает 1 место среди европейских стран и 4 место в мире по количеству проведенных циклов вспомогательных репродуктивных технологий (140931 цикл за 2020 год, 158893 за 2021 год). Однако, по данными Российской ассоциации репродукции человека и Европейского общества репродукции человека и эмбриологии, эффективность программ вспомогательных репродуктивных технологий составляет не более 40%. Лечение бесплодия методами вспомогательных репродуктивных технологий может быть неудачным по ряду основных факторов, в том числе в связи с отсутствием эффективной имплантации эмбриона в эндометрий. Одна из ведущих причин неудачи имплантации компетентного эмбриона – отсутствие формирования адгезивного матрикса между эмбрионом и эндометрием. Решающую роль в этом процессе играют скоординированные во времени дифференцировка клеток эндометрия и взаимодействие с эмбрионом. Выдвинута гипотеза, что применение сред, обогащенных гиалуроновой кислотой, при переносе эмбрионов может помочь решить проблему неудачи имплантации в программах вспомогательных репродуктивных технологий. Проведен систематический анализ литературных данных о применении культуральной среды, обогащенной гиалуроновой кислотой, при переносе эмбрионов для улучшения исходов программ вспомогательных репродуктивных технологий. Описаны возможные механизмы её действия при переносе эмбрионов в программах вспомогательных репродуктивных технологий.

Infertility is a global problem. According to the data of the World Health Organization, 17.5% of people, or one in six people worldwide, suffer from infertility as of 2023. Experts believe that by 2050, a critical decline in the birth rate will lead to a reduction in the number of children under 15 by 40% or more. In Russia, statistics reflect global trends. Therefore, the search for new, effective infertility treatments is a pressing issue in modern medicine. The objective of this review was to analyze and evaluate current data on the use of a hyaluronic acid-enriched medium during embryo transfer to increase implantation rates in infertility treatment cycles using assisted reproductive technologies. The sources of specialized literature used in this review were electronic libraries of scientific publications and medical databases such as Google Scholar, PubMed, and elibrary.ru. The review included relevant publications found through a search using the following keywords: "assisted reproductive technologies," "hyaluronic acid," "embryo," and "endometrium." The study found that the Russian Federation ranks first among European countries and fourth globally in the number of assisted reproductive technology cycles performed (140,931 cycles in 2020 and 158,893 in 2021). However, according to the Russian Association of Human Reproduction and the European Society of Human Reproduction and Embryology, the effectiveness of assisted reproductive technology programs is no more than 40%. Infertility treatment with assisted reproductive technology can be unsuccessful for a number of key factors, including the lack of effective embryo implantation in the endometrium. One of the leading causes of implantation failure of a competent embryo is the failure to form an adhesive matrix between the embryo and the endometrium. The coordinated differentiation of endometrial cells and their interaction with the embryo play a crucial role in this process. It is hypothesized that the use of hyaluronic acid-enriched culture media during embryo transfer may help address the problem of implantation failure in assisted reproductive technology programs. A systematic review of the literature on the use of hyaluronic acid-enriched culture media during embryo transfer to improve assisted reproductive technology outcomes was conducted. Possible mechanisms of action for this medium during assisted reproductive technology embryo transfer are described.

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The authors declare that there are no conflicts of interest present.