NEUROBLASTIC RESERVE OF THE HUMAN ENTERIC NERVOUS SYSTEM
https://doi.org/10.20340/mv-mn.2026.34(1).1014
Abstract
INTRODUCTION. According to the Russian classification, the enteric nervous system (ENS) is part of the metasympathetic system that unites the intramural nerve ganglia of various organs [1]. At the same time, there is not a single provision concerning its morphology that would not be controversial. First of all, this is the lack of reliable information about the physiological and reparative regeneration of the ENS, about the participation in it of stem cells, mitotically or amitotically dividing neuroblasts, neuroblastic reserve and dicaryons or heterokaryons formed by the fusion of neurons and oligodendrocytes.
AIM of the study is to prove the presence of neuroblastic reserve in the ENS in human postnatal ontogenesis.
MATERIALS AND METHODS. Autopsy fragments of the intestines of newborns (n=3) and people of mature age I (n=12) were studied using classical and original impregnation methods.
RESULTS AND DISCUSSION. The data obtained indicate that the differentiation of an markedly abundant and extremely heterogeneous population of human ENS neuroblasts continues in the postnatal period of ontogenesis. In this regard, a reserve is formed in it, due to which the population of differentiated neurocytes is constantly replenished.
About the Authors
Igor' I. Markov
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Doctor of Medical Sciences, Professor, Advisor to
the Rector
Samara
Competing Interests:
The authors declare that they have no conflicts of interest in the planning, implementation, financing and use of the results of this study
Dinara R. Nizametdinova
Medical University "Reaviz"
Russian Federation
Competing Interests:
Russian Federation
Senior Lecturer, Department of Morphology and Pathology
Competing Interests:
The authors declare that they have no conflicts of interest in the planning, implementation, financing and use of the results of this study
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For citations:
Markov I.I., Nizametdinova D.R. NEUROBLASTIC RESERVE OF THE HUMAN ENTERIC NERVOUS SYSTEM. Morphological newsletter. 2026;34(1):id-1014. (In Russ.) https://doi.org/10.20340/mv-mn.2026.34(1).1014
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