MORPHOLOGICAL CHANGES OF PERIPHERAL BLOOD CELLS AT DIFFERENT OPTIONS OF THE TREATMENT OF THE OPISTHORCHIASIS IN THE EXPERIMENT

A morphological study of the formed elements of peripheral blood in experimental animals (rabbits) induced by opisthorchiasis in the treatment Biltricid, Acorsol and Triad Premium. When applying Acorsol and Triad Premium discovered toxic granularity of the cytoplasm of segmented and band at pseudoeosinophils. Segmented shape was characterized by hypersegmented kernel. When applying Biltricid stab pseudoeosinophils in the blood is not detected. The segmented pseudoeosinophils had a pronounced toxic or grit, or completely had no granules in the cytoplasm were single or multiple vacuoles calf Knyazkova is the Case. Young forms are discovered in the application of the Triad Premium. Eosinophils in all cases had partial basophilic granules. In the cytoplasm of basophils in all groups of granules are partially absent, but to a greater extent in the treatment of Acorsol. Form Turk in contrast to the control were isolated. Forms Reader in a smaller number of detected only with the use of Acorsol. The shadows Botkin-Gumprecht-Klein considerable amount detected in the application of Biltricid and in control. In the study of red blood cells poikilocytosis detected in all cases. But when you apply Biltricid still identified anisochromia, basophilic punctuation. Thus, the most pronounced changes of erythrocytes and leucocytes was observed after treatment of opisthorchiasis Biltricid, with other drugs and control. But unlike Biltricid, in the treatment of opisthorchiasis Triad Premium and Acorsol visually, there was an increase in the size of blood platelets. When morphometry diameter pseudoeosinophils and eosinophils in animals with the treatment and the control was normal according to the literature. However, without treatment, the diameter of pseudoeosinophils and eosinophils was greater than in cells of animals with all treatment options. There were no significant differences in the diameter of eosinophils in the treatment with Triad Premium and Biltricide.

opisthorchiasis, blood, blood cells, Biltricid, Acorsol, Triad Premium

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