ULTRASTRUCTURAL CHANGES OF CELLS OF THE GASTRIC MUCOSA AT ASTHMA

The asthma is a multi-functional pathology, which is based on cellular and humoral mechanisms of the damage to various organs and tissues. Most often the digestive system is involved in this pathological process. The aim of the research was investigate ultra-structural features of cells of the gastric mucosa as the central organ in the digestive and having more different populations of cells involved in different functions in the asthma of varying severity. The material for the study was the biopsy specimens of the stomach from 19 patients with controlled asthma mild, from 15 patients with bronchial asthma of moderate severity and from 12 patients with a severe degree. Semi-thin sections were examined on a optic binocular microscope with the digital analyzer; ultra-thin sections were examined on a transmission electron microscope. The article present results of ultra-structural studies of disorders of stomach cells at the bronchial asthma. Authors found that at different severity of asthma observed characteristic for each group of abnormalities in epithelial secretory cells and in cells of the lamina propria of the mucous membranes. It is revealed that integrated basic therapy of bronchial asthma of moderate severity has a membrane-stabilizing effect on the cells of the mucosa, but in all groups can be traced ultra-structural changes of organelles in the proximal and in the distal stomach. In article presents some ultra-structural evidence of the cell-tissues remodeling process in different parts of the stomach in the bronchial asthma.

бронхиальная астма, слизистая оболочка желудка, ультраструктурная патология, ремоделирование, bronchial asthma, stomach mucosa cells, ultra-structural pathology, remodeling

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