THE SEX-SPECIFIC MORPHOLOGICAL DIFFERENCES OF MUCOSAL LAYER OF COLON IN ADULT C57BL/6 MICE
https://doi.org/10.20340/mv-mn.2015.0(1):18-24
Abstract
The morphofunctional differences of colon between sexes are not well studied. The goal of this research is to study the sexual difference of structural components of mucosal layer in different parts of colon in adult mice of C57BL/6 strain. The body mass and the length of colon were evaluated and the morphological and morphometric evaluation of mucosal layer were conducted in adult male and female mice of C57BL/6 strain. In comparison with adult females, males tended to have more body weight and longer colon. In colon mucosa, especially in the distal colon, there was greater volumetric proportion of goblet cells and other cell elements, which could reflect the greater intensity of mucosal and immunological compartments. These sex differences in hystophysiology of colon and its parts, evidently, predetermine the course of pathological processes in different parts of colon and in different sexes.
About the Author
Y. . Gao
МГУ им. М.В. Ломоносова; ФГБНУ «НИИ морфологии человека» РАН
Russian Federation
Russian Federation
References
1. Lampe J.W., Fredstrom S.B., Slavin J.L., Potter J.D. Sex differences in colonic function: a randomized Trial// Gut. - 1993 - №34(4). - p. 531-536.
2. Eliakim R., Abulafia O., Sherer D.M. Hyperemesis gravidarum: a current review// Am. J.Perinatol. -2000 - №17(4). - p.207-18.
3. Heitkemper M.M., Shaver J.F., Mitchell E.S. Gastrointestinal symptoms and bowel patterns across the menstrual cycle in dymenorrheic and nondymenorrheic women// Nurs.Res. - 1988 -№37(2). - p.108-113.
4. Kane S., Stone L.J., Ehrenpreis E. Thalidomide as "salvage” therapy for patients with delayed hypersensitivity response to infliximab: a case series// J. Clin. Gastroenterol. - 2002 - №47(3). -p. 149-150.
5. Kamm M.A., Fartning M.J. G. and Lennard-Jones J.E. Bowel function and transit rate during the menstrual cycle// Gut. - 1989 - №30(5). - p. 605-608.
6. Camilleri M., Atanasova E., Carlson P.J., Ahmad U., Kim H.J., Viramontes B.E., McKinzie S., Urrutia R. Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome// Gastroenterology. - 2002 -№123(2). - p.425-432.
7. Scherl E., Frissora C.L. Irritable bowel syndrome genophenomics: correlation of serotonin-transporter polymorphisms and alosetron response// Pharmacogenomics. J. - 2003 - №41. - p. 64-66.
8. Кабак Я.М. Практикум по эндокринологии//М.: изд-во МГУ. -1968 -. 275 с.
9. Moss R., Parkinson J.A. The digestion of heather (Calluna vulgaris) by red grouse (Lagopus lagopus scoticus)// Br J Nutr - 1972 - р.285-298.
10. Pullianien E., Tunkkari P. Seasonal changes in the gut length of the willow grouse (Lagopus lagopus) in Finnish Lapland //Ann. Zool. Fennici. - 1983 - №20. - p.53-56.
11. Zecchini V., Domaschenz R., Winton D., Jones P. Notch signaling regulates the differentiation of postmitotic intestinal epithelial cells//Genes. Dev. - 2005 - №12. - p. 1686-1691.
12. Van Es J.H., Jay P., Gregorieff A., van Gijn M.E., Jonkheer S., Hatzis P., Thiele A., van den Born M., Begthel H., Brabletz T., Taketo M.M., Clevers H. Wnt signalling induces maturation of Paneth cells in intestinal crypts// Nat. Cell. Biol. - 2005 - №3. - p. 381-386.
13. Wang Xi-De, Ching Ching Leow, Jiping Zha, Zhijun Tang. Notch signaling is required for normal prostatic epithelial cell proliferation and differentitiation// Developmental Biologi. - 2006 - №290. - p. 286-294.
14. Bufill J.A. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location// Ann. Intern. Med. - 1990 - №113(10). -p.779-788.
15. Bonithon-Kopp C., Benchamiche A.M. Are there several colorectal cancers? Epidemiological data// Eur. J. Cancer. Prev. - 1999 - №8(1). - p.3-12.
16. Glebov O.K., Rodriguez L.M., Nakahara K., Jenkins J., Cliatt J., Humbyrd C.J., DeNobile J., Soballe P., Simon R,. Wright G., Lynch P., Patterson S., Lynch H., Gallinger S., Buchbinder A., Gordon G., Hawk E., Kirsch I.R. Distinguishing right from left colon by the pattern of gene expression// Cancer. Epidemiol. Biomarkers. Prev. - 2003 - №12(8). -p.755-762.
17. Белоусова Е.А. Иммунные механизмы при воспалительных заболеваниях кишечника и принци пы селективной иммунокорреции// Российский журнал гастроэнтерологии, гепатологии, коло-проктологии. - 1992 - № 7. - с. 2-10.
Review
For citations:
Gao Y. THE SEX-SPECIFIC MORPHOLOGICAL DIFFERENCES OF MUCOSAL LAYER OF COLON IN ADULT C57BL/6 MICE. Morphological newsletter. 2015;23(1):18-24. (In Russ.) https://doi.org/10.20340/mv-mn.2015.0(1):18-24
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