Histological characteristics of rete ovarii in acute period of genital herpes virus infection

Structural and functional states of the rete ovarii were investigated in healthy mature females Guinea pigs and Guinea pigs during the acute phase of genital herpes virus infection. The methods of light and transmission electron microscopy, immunohistochemical analysis of alpha-receptors to estrogenes, immunofluorescence studies of herpes simplex virus antigens, quantitative morphometry were used. In the acute phase of genital herpes infection all animals had the multi cystic transformation of the rete ovarii in the background of overt signs of inflammation in the medulla of the ovaries; also a decrease in the activity of immunohistochemical labelling of nuclei of epithelial cells of the rete ovarii to the alpha-receptor of estrogenes and immunofluorescent staining of the nuclei of these cells to the virus antigens was registered. Therefore negative effects of the herpes simplex virus on the regulatory effects of estrogenes and morphophysiology of rete ovarii with the outcome in cystic transformation were showed.

сеть, яичник, герпес, вирус, транскрипция, киста, rete ovarii, herpes, virus, transcription, cyst

1. О.В. Волкова, Т.Г.Боровая, Е.О.Погорельская, В.А.Степаненко. Морфогенетическая роль сети в физиологии и патологии яичников//Медико-биологические науки. - 2002. - № 4. - С. 21 - 22.

2. Е. Н. Карева, О. М. Олейникова, В. О. Панов, Н. Л. Шимановский, В.И. Скворцова. Эстрогены и головной мозг // Вестник РАМН. - 2012. - № 2. - С. 48 - 9

3. Ф.А. Шаповалов, Т.Г. Боровая, Г.Г. Кругликов, Л.М. Каппушева. Морфологические особенности овариальной сети крыс в периоды репродукции и старения//Бюлл.эксп.биол., мед. - 2012. - Т. 154 (12). - С. 772 - 4

4. Acikalin M.F., Tokar B. Giant cyst ofthe rete ovarii in a child//J PediatrSurg. - 2005 -. V. 40(6). - P. 17 - 19.

5. Anower A.K., Shim J.A., Choi B., Kwon H.J., Sohn S. The role of classical and alternative macrophages in the immunopathogenesis of herpes simplex virus-induced inflammation in a mouse model//J. Dermatol. Sci. - 2014. - Vol. 73 (3). - P. 198 - 208.

6. Byskov A.G. The role of the rete ovarii in meiosis and follicle formation in the cat, mink, and ferret//J Reprod Fertil. - 1975. - V. 45. - P. 201 - 209.

7. Byskov A.G., Skakkebaek N.E., Stafanger G., et al. Influence of ovarian surface epithelium and rete ovarii on follicle formation//J Anat. - 1977. V. - 123. - P. 77 - 86.

8. Crum, C. P. The female genital tract: Ovarian tumors. - 2005. - P. 1093-1104. In: Robbins and Cotran Pathologic Basis of Disease, 7th ed. (Kumar, V., Abbas, A.K. and Fausto, N. eds.) Elsevier Saunders, Philadelphia.

9. Jiang J., Take Y., Kobayashi Y., et al. Adenomatous hyperplasia of the rete ovarii in beagle//J Toxicol Pathol. - 2004. - V. 17. - P. 127 - 128.

10. Keller L.S., Griffith J.W., Lang C.M. Reproductive failure associated with cystic rete ovarii in guinea pigs//Vet Pathol. - 1987. - V. 24(4). - P. 335 - 9.

11. Knipe D.M. The role of viral and cellular nuclear proteins in herpes simplex virus replication//Adv. Virus Res. - 1989. - Vol. 37. - P. 85 - 123.

12. Kon Y., Konno A., Hashimoto Y., et al. Ovarian cysts in MRL/MpJ mice originate from rete ovarii//Anat Histol Embryol. - 2008. - V. 36. P. 172 - 178.

13. Lee S., Ichii O., Otsuka S., et al. Quantitative trait locus analysis of ovarian cysts derived from rete ovarii in MRL/MpJ mice//Mamm Genome. - 2010. - V. 21. - P. 162 - 171.

14. Lee S.H., Ichii O., Otsuka S., Hashimoto Y., Namiki Y., Kon Y. Identifying a new locus that regulates the development of rete ovarian cysts in MRL/MpJ mice// Jpn J Vet Res. - 2011. - V. 59(2-3). - P. 79 - 88.

15. McInerney E.M., Weis K.E., Sun J., Mosselman S., Katzenellenbogen B.S. Transcription activation by the human estrogen receptor subtype beta (ER beta) studied with ER beta and ER alpha receptor chimeras//Endocrinology. - 1998. - Vol. 139 (11). -P. 4513 - 22.

16. Pilny A. Ovarian cystic disease in guinea pigs// Vet Clin North Am Exot Anim Pract. - 2014. - V. 17(1). - P. 69 - 75.

17. Quattropani S.L. Serous cysts of the aging guinea pig ovary. II. Scanning and transmission electron microscopy//Anat Rec. - 1978. - V. 190(2). - P. 285 - 98.

18. Shi F., Petroff B.K., Herath C.B., Ozawa M., Watanabe G., Taya K. Serous cysts are a benign component of the cyclic ovary in the guinea pig with an incidence dependent upon inhibin bioactivity//J Vet Med Sci. -2002. - V. 64(2). - P. 129 - 35.

19. Sung-Woo, Yong-Hoon, Sang-Rae, Kyoung-Min, Young-Jeon, Kang-Jin, Kwon-Sik, Doo, Hwa-Young, Dong-Suck and Kyu-Tae Bilateral Ovarian Cysts Originating from Rete Ovarii in an African Green Monkey(Cercopithecus Aethiops) online in J-STAGE 21 May 2012.

20. Upadhyay S., Luciani J.M., Zamboni L. The role of the mesonephros in the development of indifferent gonads and ovaries of the mouse//Ann Biol Anim Biochim Biophys. - 1979. - V. 19. - P. 1179 - 1196.

21. Waterberg H. Development of the early human ovary and role of the mesonephros in the differentiation of the cortex//Anat Embryol. - 1982. -V. 165. - P. 253 - 280.

22. Wenzel J.G., Odend’hal S. The mammalian rete ovarii: a literature review//Cornell Vet. - 1985. - V. 75. - P. 411 - 425.

23. Wenzel J.G., Odend’hal S., Player E.C. Histological and histochemical characterization of the bovine rete ovarii through the estrous cycle and gestation.//Anat Histol Embryol. - 1987. - Vol. 16(2). - P. 124-35.