Submicroscopic changes of the cells of the duodenal mucosa at bronchial asthma
https://doi.org/10.20340/mv-mn.2014.0(2):6-12
Abstract
Asthma is the leading allergic disorder. Organs of the digestive system are often involved in this pathological process. There is currently no complex morphological research of the response of the mucous membranes of the gastrointestinal tract to allergic injury and to various methods of treatment of asthma. The aim of this study was to determine the morphological ultra structural features of the duodenal mucosa cells in bronchial asthma of varying severity. As a material for research we used duodenum biopsies of 19 patients with controlled mild asthma, 15 patients with asthma of moderate severity and 12 patients with severe asthma. Semi thin sections were studied in the light microscope with digital image analyzer. Ultra thin sections were examined by transmission electron microscope. It was established that statistically significant morphological violations in the secretors and epithelial cells of duodenum mucosa were observed for each group at different severity of bronchial asthma. It was revealed that complex basic therapy of bronchial asthma of moderate severity had a stabilizing effect on epithelial cells of duodenum. The possibility of extending the remodeling process on organs of the gastrointestinal tract in bronchial asthma is discussed.
About the Authors
V. E. Golovanova
ФГБУ «Научно-исследовательский институт морфологии человека» РАМН
Russian Federation
Russian Federation
T. G. Barkhina
ФГБУ «Научно-исследовательский институт морфологии человека» РАМН
Russian Federation
Russian Federation
L. M. Mikhaleva
ФГБУ «Научно-исследовательский институт морфологии человека» РАМН
Russian Federation
Russian Federation
V. P. Chernikov
ФГБУ «Научно-исследовательский институт морфологии человека» РАМН
Russian Federation
Russian Federation
References
1. Parameswaran Nair, Sergei I Ochkur, Cheryl Protheroe, Elizabeth Simms. The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma. Allergy Asthma Clin Immunol 2011; 7(1): 4.
2. Pires GV, Souza HS, Elia CC, Zaltman C. Small bowel of patients with asthma and allergic rhinitis: absence of inflammation despite the presence of major cellular components of allergic inflammation. Allergy Asthma Proc 2012; 25(4):253-9.
3. Shirai T, Komiyama A, Hayakawa H. Eosinophil-associated gastrointestinal disorders with asthma: immunohistochemical analyses. Intern Med 2009; 48(15):1315-21.
4. Golovanova V.E., Mikhaleva L.M., Barkhina T.G., Schegoleva N.N., Gracheva N.A., Ivanova E.V. Patomorfologicheskaja harakteristika gastroduodenal’noj zony pri persistirujushhej bronhial’noj astme legkoj stepeni tjazhesti. Fundamental’nye issledovanija (Rus) 2012; 4(1): 42-46.
5. Mihaleva L.M., Barkhina T.G., Schegoleva N.N., Gracheva N.A. Lekarstvennyj patomorfoz hronicheskogo jezofagita, gastrita i duodenita u bol’nyh bronhial’noj astmoj. In book: Tezisy dokladov XI Moskovskoj Assamblei «Zdorov’e stolicy». Moskva, 13-14 dekabrja 2012 goda (Rus) 2012: 171-172.
6. Nemtcov V.I., Aleksandrova R. A., Magidov M.Ja. Osobennosti bronhial’noj astmy u bol’nyh s patologiej gastroduodenal’noj zony. Allergologija (Rus) 2009; 4:18-21.
7. Nepomnjaschih D.L., Lapij G.A., Ajdagulova S.V. i soavt. Biopsija v gastrojenterologii: morfogenez obshheatologichesih processov. Pod red. Nepomnjashhih G.I. (Rus). Moscow: «Izdatel’stvo RAMN». 2010: 433p.
8. Golovanova V.E., Barkhina T.G., Mikhaleva L.M., Chernikov V.P., Judina E.B. Kletochnye i vnutrikletochnye reakcii dvenadcatiperstnoj kishki pri persistirujushhej bronhial’noj astme legkoj i srednej stepeni tjazhesti In book: Aktual’nye voprosy morfogeneza v norme i patologii: Sbornik nauchnyh trudov konferencii (Rus). Moskva, 2012: 33-38.
9. Mkihaleva L.M., Barkhina T.G., Golovanova V.E., Schegoleva N.N., Gracheva N.A. Jeozinofil’nyj jezofagit pri bronhial’noj astme. Obzor literatury. Klinicheskaja medicina (Rus) 2012; 6:7-11.
10. Mikhaleva L.M., Barkhina T.G., Schegoleva N.N., Gracheva N.A. Sravnitel’naja morfologija slizistoj obolochki zheludka u pacientov s bronhial’noj astmoj pri ingaljacionnoj gljukokortikosteroidnoj terapii. Arhiv patologii (Rus) 2013; 75(2):9 -15.
11. Guschin M.Ju., Golovanova V.E., Barkhina T.G., Pol’ner S.A. Sravnitel’naja harakteristika klinicheskih i morfologicheskih aspektov u pacientov razlichnogo vozrasta pri bronhial’noj astme. Fundamental’nye issledovanija (Rus) 2011; 6:49-53.
12. Guschin M.Ju., Golovanova V.E., Barkhina T.G., Pol’ner S.A. Jepidemiologicheskie i kliniko-morfologicheskie aspekty allergicheskogo rinita i bronhial’noj astmy u pacientov razlichnogo vozrasta. Rossijskij allergologicheskij zhurnal (Rus) 2011; 4(1): 97-100.
13. Guschin M.Yu., Barkhina T.G., Golovanova V.E., Polner S.A. Bronchial asthma and allergic rhinitis: slinical, immunological and morphological features. European Respiratory Journal 2011; (38) Suppl. 55: 981.
Review
For citations:
Golovanova V.E., Barkhina T.G., Mikhaleva L.M., Chernikov V.P. Submicroscopic changes of the cells of the duodenal mucosa at bronchial asthma. Morphological newsletter. 2014;22(2):6-12. (In Russ.) https://doi.org/10.20340/mv-mn.2014.0(2):6-12
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