THE MORPHOMETRIC ANATOMY OF THE EYE SHELLS IN THE INTERMEDIATE FETAL PERIOD OF HUMAN ONTOGENESIS
Abstract
The study of the processes of eye morphogenesis in the fetal period of ontogenesis is relevant from the point of view of understanding the mechanisms of the formation of physiological hyperopia in newborns and myopia in childhood later. The greatest transformations in the human fetus are subject to changes in the cornea and shells of the eyeball in the equator area and in the optic nerve disk area. In general, the eyeball grows and develops most actively in the intermediate fetal period of ontogenesis. However, the details of this process are not well understood. The aim of the study is to characterize the quantitative macro-microscopic anatomy of the shells of the eyeball in a human fetus in the intermediate fetal period of ontogenesis. Macroscopically and microscopically, the anatomy of the orbit and eyeball of the fetus at the age of 14-27 weeks was studied by histo-topography. Three age groups were studied: Group I (14-18 weeks) - 36% of observations, Group II (19-23 weeks) - 38% of observations, Group III (24-27 weeks) - 26% of observations, of which 50% of observations male and 50% female. Histo-topograms made it possible to characterize the morphology of all shells of the eyeball (fibrous, choroid and retina), as well as to trace their course in all its parts. The description of the mid-horizontal and mid-sagittal histo-tomograms, stained according to Van Gieson, is presented and a quantitative characteristic of the thickness of all shells of the eyeball in the equator, the posterior pole of the eye and the cornea is given, sex differences are established and their growth rates are indicated. In the intermediate fetal period of human ontogenesis, the anterior-posterior size of the eyeball changes from 6.91±1.22 mm to 12.25±1.61 mm. At some stages of the entire intermediate fetal period of human ontogenesis, the ratio of the thickness of the shells of the eye is comparable (thickness of the sclera - 51%, of the choroid - 29%, of the retina - 20%). The study of the growth rate of the thickness of the shells of the eyeball revealed its greatest increase in the studied period of ontogenesis in the region of the posterior pole (69.06%).
Supporting agencies: The research study was carried out with the fi-nancial support of a grant of the Orenburg State Medical University (Order No. 66 of January 17, 2020, On the approval of the Program «University Scientific Grant»- 2020)
About the Authors
Svetlana I. Naydenova
Orenburg State Medical University, Orenburg
Russian Federation
Competing Interests:
Russian Federation
Assistant of the Human Anatomy Department
Competing Interests:
The author declares that he did not have any conflicts of interest in the planning, implementation, financing and use of the results of this study
Elena D. Lutsay
Orenburg State Medical University, Orenburg
Russian Federation
Competing Interests:
Russian Federation
Doctor of Medical Sciences, Docent, Professor of the Human Anatomy Department
Competing Interests:
The author declares that he did not have any conflicts of interest in the planning, implementation, financing and use of the results of this study
Igor V. Astaf'ev
Orenburg State Medical University, Orenburg
Russian Federation
Competing Interests:
Russian Federation
Candidate of Medical Sciences, Assistant Professor of the Department of Ophthalmology
Competing Interests:
The author declares that he did not have any conflicts of interest in the planning, implementation, financing and use of the results of this study
References
1. Askarova ZF, Gorbatjuk TL, Bojchuk IM. Morfostrukturnye osobennosti zritel'nogo nerva i peripapilljarnyh volokon u detej s miopiej. Oftal'mologicheskij zhurnal. 2011;1(438):41-45.
2. Jan WT, Jan RP, Vincent WJ. Growth in Foetal Life, Infancy, and Early Childhood and the Association With Ocular Biometry. Ophthalmic Physiol Opt. 2019;39(4):245-252. DOI: 10.1111/ opo.12630.
3. Leo SW. Current approaches to myopia control. Curr. Opin. Ophthalmol. 2017;28(3):267-275. DOI: 10.1097/ICU.0000000000000367.
4. Levy N, Shinwell ES, Leiba H. Long-term Refractive Status of Preterm Infants From Singleton and Multiple Pregnancies. J Matern Fetal Neonatal Med. 2017;30(19):2276-2280. DOI: 10.1080/14767058.2016.1245719.
5. Lucaj ED, Najdenova SI, Astaf'ev IV. Analiz sostojanija voprosa o razvitii i stroenii glaznogo jabloka i nekotoryh vspomogatel'nyh struktur glaza (obzor literatury). Morfologija. 2019;155(3):66-72.
6. Jonas JB. Myopia: Epidemiology, anatomy and prevention of myopia and treatment options for progressive myopia in childhood. Ophthalmologe. 2019;116(6):498. DOI: 10.1007 / s00347-019-0891-5.
7. Koshic IN, Svetlova OV. Mehanizm formirovanija adekvatnoj dliny glaza v norme i metabolicheskaja teorija patogeneza priobretennoj miopii. Oftal'mologicheskij zhurnal. 2011;5(442):4-23.
8. Wei JS, Cheryl SN, Hong P. In-utero Epigenetic Factors Are Associated With Early-Onset Myopia in Young Children. PLoS One. 2019;17:1-25. DOI: 10.1371 / journal.pone.0214791.
9. Kagan II, Kanjukov VN. Funkcional'naja i klinicheskaja anatomija organa zrenija. Moskva: GJeOTAR-Media, 2017.- 208s.
10. Pjetten BM. Jembriologija cheloveka. M.: Medgiz. 1959.- 801s.
11. Stepanova IP, Lysov PK, Kargina AS. Razvitie i stroenie zritel'nogo nerva v rannem jembriogeneze cheloveka. Zhurnal anatomii i gistologii. 2015;3:115-116.
12. Denis D. Congenital abnormalities of the optic disc. J.Fr. Ophthalmol. 2019;42(7):778-779. DOI: 10.1016 / j.jfo.2018.09.011.
The authors investigated the processes of eye morphogenesis in the intermediate fetal period of human development from the point of view of understanding the mechanisms of the formation of physiological hyperopia in newborns and myopia in childhood
Review
For citations:
Naydenova S.I., Lutsay E.D., Astaf'ev I.V. THE MORPHOMETRIC ANATOMY OF THE EYE SHELLS IN THE INTERMEDIATE FETAL PERIOD OF HUMAN ONTOGENESIS. Morphological newsletter. 2021;29(2):51-57. (In Russ.)
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