MORPHOLOGICAL CHANGES OF THE BONE MARROW IN THE EXPERIMENTAL OPISTHORCHIASIS

Abstract

Some studies indicate cytotoxic manifestations of opisthorchiasis in the morphological changes in the elements of peripheral blood. However, these effects have specificity in different animal species. An experimental study of hematopoietic cells and stromal components of bone marrow in rabbits after 4 months after infection of opisthorchiasis was made. The changes of only the cells of the myelocytic part of the hemopoietic component were revealed. A violation of tinctorial properties and nuclear structure of the eosinophilic pseudo-eosinophilic promyelocytes retain this feature on the myelocytic stage as well as the absence and in uneven distribution of grain and eosinophilic pseudo-eosinophilic myelocytes, metamyelocytes, also are natural lag changes in grain tinctorial properties in ripening eosinophilic form of cells. Lymphoblasts were with vacuolated cytoplasm, nucleus and nucleoli without discolored cytoplasm. Rarely met when assessing the morphology of erythrocyte germ oxyphilic normocytes and reticulocytes, which characterizes the oppression of the final stages of erythropoiesis. The variability of megakaryocytes was combined with cells with nude nuclei , which confirm the active functionality of these forms in opisthorchiasis. Thus, in opisthorchiasis immature nuclei was found in the bone marrow cells in maturing, which lags by stages of maturation within 1-2 transitional forms, also the violation of tinctorial properties graininess in pseudo-eosinophilic granulocyte stages and megakaryocytes cytomorphology.