Fibronectin of the thyroid gland in dogs at single and multiple muscle loads
https://doi.org/10.20340/mv-mn.2016.24(4):81-85
Abstract
Fibroneetin (FN) plays a role in the differentiation, growth, maintenance of normal morphology, proliferation and apoptosis of cells, their migration and spatial organization, ineluding due to remodeling of the vascular and nervous supply. The aim of the study is FN in the thyroid gland (TG) after various types of muscular activity. The control thyroid-intact male dogs (16) have no running. Six experimental groups include 67 dogs with different models of running (from a few minutes to a few months). Monoclonal antibodies were used to isolate FN. Sections of the right lobe of TG were digitizing and areas were measured after qualitative analysis. Areas of FN after single loads with middle running time and multiple loads (from one to three months) did not differ significantly from the control. Areas of FN in two groups (single loads with minimum running time and single loads with maximum running time) were more than in the control group and they are significantly different from each other. The heart rate and vascular supply of TG increased; morphologie signs of thyroid proliferation were present at dogs of these groups. Accumulation of intravascular faction of FN was recognized at the single loads with minimum running time. Accumulation of interfollicular and intrafollieular factions of FN was found at the single loads with maximum running time, it is possible due to the activation of thyroeytes. Thus, fibronectin, which is traditionally regarded as a marker of tumors of the thyroid gland, can serve as a reflection of proliferative activity of thyrocytes after the muscle loads.
About the Author
A. V. Bezdenezhnykh
ФГБОУ ВО «Нижегородская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Bezdenezhnykh A.V. Fibronectin of the thyroid gland in dogs at single and multiple muscle loads. Morphological newsletter. 2016;24(4):81-85. (In Russ.) https://doi.org/10.20340/mv-mn.2016.24(4):81-85
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