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The influence of kiss-peptin on estrous cycle of rats

https://doi.org/10.20340/mv-mn.2014.0(2):34-40

Abstract

36 mature young female Wistar rats conducted an experimental study of the effect of pharmacological blockade kisspeptine receptors on rat’s estrous cycle. Found that kisspeptin has a regulating effect on the estrous cycle of rats. The block of kisspeptine receptors leads to a prolonged disruption of the estrous cycle, consisting in the ovulation phase disappearance and the development of secondary infertility.

About the Authors

E. G. Zarubina
НОУ ВПО «Самарский медицинский институт «РЕАВИЗ»
Russian Federation


A. N. Lysova
НОУ ВПО «Самарский медицинский институт «РЕАВИЗ»
Russian Federation


V. I. Belakov
НОУ ВПО «Самарский медицинский институт «РЕАВИЗ»
Russian Federation


References

1. Matsui H., Tanaka A., Yokoyama K., Takatsu Y. et аl. Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats // Endocrinology.-2012.- Vol.153. - N 11.-P. 5297-5308.

2. Matvienko M. G., Pustovalov A. S., Dzerzhinsky N. E. Variety of functions and effects of kisspeptin // Biopolymers and Cell. -2013.- Vol. 29. -N 1. -P. 11-20

3. Oakley, Amy E., Clifton, Donald K., Steiner, Robert A. Kisspeptin Signaling in the Brain //Endocrine Reviews.- 2009. - Vol.30. -№6. - Р. 713-743.

4. Ong, K.K., Emmett, P., Northstone et аl. Infancy weight gain predicts childhood body fat and age at menarche in girls.//J. Clin. Endocrinol. Metab. - 2009.- №94 - Р. 1527-1532.

5. Woller, M.J., Tannenbaum, P.L., Schultz-Darken, N.J., Eshelman, B.D., Abbott, D.H. Pulsatile gonadotropin-releasing hormone release from hypothalamic explants of male marmoset monkeys compared with male rats. // Am. J. Physiol.Regul. Integr. Comp. Physiol. - 2010. - №298. - R70-R78


Review

For citations:


Zarubina E.G., Lysova A.N., Belakov V.I. The influence of kiss-peptin on estrous cycle of rats. Morphological newsletter. 2014;22(2):34-40. (In Russ.) https://doi.org/10.20340/mv-mn.2014.0(2):34-40

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