THE INFLUENCE OF THE INFLAMMATORY MEDIATORS ON THE PERIPHERAL BLOOD MONOCYTES IN THE NORMAL CONDITIONS AND IN ENDOTOXICOSIS
https://doi.org/10.20340/mv-mn.2014.0(3):52-58
Abstract
It was revealed that in endotoxicosis the process of apoptosis in peripheral blood monocytes intensifies. But the number of cells dying by necrosis increases as well. The determination of the ratio of viable cells, the number of cells dying by apoptosis and necrosis, may serve as the predictor of estimation the severity of endotoxicosis, prospects for a favorable outcome and a successful treatment of the disease. Hydrogen peroxide, histamine, serotonin, however with the different proapoptotic activity, affect on the start of apoptosis program in donor’s blood monocytes and in the blood monocytes of the patients with endotoxicosis.
About the Authors
E. N. Lopukchova
ФГБОУ ВПО «Мордовский государственный университет имени Н.П. Огарёва»
Russian Federation
Russian Federation
V. A. Trofimov
ФГБОУ ВПО «Мордовский государственный университет имени Н.П. Огарёва»
Russian Federation
Russian Federation
A. P. Vlasov
ФГБОУ ВПО «Мордовский государственный университет имени Н.П.Огарёва»
Russian Federation
Russian Federation
References
1. Бородин Е.А. Биохимия эндотокситоза. Механизмы развития и оценка степени тяжести при воспалительных заболеваниях легких / Е. А. Бородин, Е. В. Егоршина, В. П. Самсонов - Благовещенск. : АГМА. - 2003. - 129 с.
2. Келина Н. Ю. Биохимические проявления эндотоксикоза: методические аспекты изучения и оценки, прогностическая значимость (аналитический обзор) / Н. Ю. Келина, Н. В. Безручко, Г. К. Рубцов //Медико-биологические науки - 2012. - №6. - С. 143-147.
3. Sheel M. The diverse roles of monocytes in inflammation caused by protozoan parasitic diseases / M. Sheel and Ch. R. Engwerda // Trends in Parasitology -2012. - Vol. 28, No. 10. - P. 408-416.
4. Haveman J. W. The central role of monocytes in the pathogenesis of sepsis: consequences for immunomonitoring and treatment/ J.W. Haveman, A.C. Muller Kobold, J.W. Cohen Tervaert et al.//The Netherlands Journal of Medicine - 1999. - Vol.55. -P. 132-141.
5. Koussoulas V. Monocytes in systematic inflammatory response syndrome: Differences between sepsis and acute pancreatitis / V. Koussoulas, M. Tzivras, V. Karagianni et al. // World J Gastroenterol - 2006. -Vol. 12, No. 41. - P. 6711-6714.
6. Shih C. M. Nickel ions from a corroded cardiovascular stent induce monocytic cell apoptosis: Proposed impact on vascular remodeling and mechanism / C.M. Shih, C.Y. Huang, L.R. Liao, et al.// J. Formos Med. Assoc. - 2014. - published Online: May 16
7. Цыпленкова В. Г. Апоптоз / В.Г. Цыпленкова, Н.Н. Бескровнова//Арх. патол. - 1996. - Т.58, № 5. - С. 71-74.
8. Elmore S. Apoptosis: A review of programmed cell death / S. Elmore. Toxicology and Pathology, 2007. Vol. 35, № 4, P. 495-516.
9. Лушников Е. Ф. Гибель клетки (апоптоз) / Е. Ф. Лушников, А.Ю. Абросимов- М. : Медицина, 2001. 190 с.
10. Пальцев М. А. Молекулярная медицина и прогресс фундаментальных наук / М. А. Пальцев // Вестник РАН. - 2002. - Т. 72, № 1. - С. 13-21.
11. Карпищенко А. И. Медицинские лабораторные технологии и диагностика : в 2 т. Т.2 / А. И. Карпищенко и др. - СПб: Интермедика. - 1999. - - 656 с.
12. Пальцев М. А. Межклеточные взаимодействия - 2-е изд., перераб. и доп. / М. А. Пальцев, А. А. Иванов, С. Е. Северин - М.: Медицина, 2003. -288 с.
13. Borodin E. А. Biokhimiya ehndotoksitoza. Mekhanizmy razvitiya i otsenka stepeni tyazhesti pri vospalitel’nykh zabolevaniyakh legkikh / E. А. Borodin, E. V. Egorshina, V. P. Samsonov -Blagoveshhensk. : АGMА. - 2003. - 129 s.
14. Kelina N. Yu. Biokhimicheskie proyavleniya ehndotoksikoza: metodicheskie aspekty izucheniya i otsenki, prognosticheskaya znachimost’ (analiticheskijobzor) /N. Yu. Kelina, N. V. Bezruchko, G. K. Rubtsov//Mediko-biologicheskie nauki - 2012. - №6. - S. 143-147.
15. Sheel M. The diverse roles of monocytes in inflammation caused by protozoan parasitic diseases / M. Sheel and Ch. R. Engwerda // Trends in Parasitology -2012. - Vol. 28, No. 10. - P. 408-416.
16. Haveman J.W. The central role of monocytes in the pathogenesis of sepsis: consequences for immunomonitoring and treatment/J.W. Haveman, A.C. Muller Kobold, J.W. Cohen Tervaert et al.//The Netherlands Journal of Medicine - 1999. - Vol.55. -P. 132-141.
17. Koussoulas V. Monocytes in systematic inflammatory response syndrome: Differences between sepsis and acute pancreatitis / V. Koussoulas, M. Tzivras, V. Karagianni et al.// World J Gastroenterol - 2006. - Vol. 12, No. 41. - P. 6711-6714.
18. Shih C.M. Nickel ions from a corroded cardiovascular stent induce monocytic cell apoptosis: Proposed impact on vascular remodeling and mechanism / C.M. Shih, C.Y. Huang, L.R. Liao, et al. // J. Formos Med. Assoc. - 2014. - published Online: May 16
19. Tsyplenkova V.G. Аpoptoz / V.G. Tsyplenkova, N.N. Beskrovnova//Агkh. patol. - 1996. - T.58, № 5. - S. 71-74.
20. Elmore S. Apoptosis: A review of programmed cell death / S. Elmore. Toxicology and Pathology, 2007. Vol. 35, № 4, P. 495-516.
21. Lushnikov E. F. Gibel’ kletki (apoptoz) / E. F.Lushnikov, А.YU. Аbrosimov- M. : Meditsina, 2001. 190 s.
22. Pal’tsev M. А. Molekulyarnaya meditsina i progress fundamental’nykh nauk/ M. А. Pal’tsev// Vestnik RАN. - 2002. - T. 72, № 1. - S. 13-21.
23. Karpishhenko А. I. Meditsinskie laboratornye tekhnologiii diagnostika : v2t. T. 2/А. I. Karpishhenko i dr. - SPb: Intermedika. - 1999. - 656 s.
24. Pal’tsev M. А. Mezhkletochnye vzaimodejstviya -2-e izd., pererab. i dop. /M. А. Pal’tsev, А. А. Ivanov, S. E. Severin - M.: Meditsina, 2003. - 288s.
Review
For citations:
Lopukchova E.N., Trofimov V.A., Vlasov A.P. THE INFLUENCE OF THE INFLAMMATORY MEDIATORS ON THE PERIPHERAL BLOOD MONOCYTES IN THE NORMAL CONDITIONS AND IN ENDOTOXICOSIS. Morphological newsletter. 2014;22(3):52-58. (In Russ.) https://doi.org/10.20340/mv-mn.2014.0(3):52-58
Views:
260
