Cell mechanisms of chronic neuroinflamation
https://doi.org/10.20340/mv-mn.2014.0(4):26-31
Abstract
Neuroinflammation can develop long before the death of neurons. We investigated the deferred effects of a lipopolysaccharide single injection in the rat substantia nigra to identify the molecular and cellular mechanisms of persistent neuroinflammation. After 8 weeks, there was a large number of microglia and astrocytes with high expression of MHC II and glial fibrillary acidic protein, respectively. The observed reaction is accompanied by the induction tumor necrosis factor-а in the walls of blood vessels and migration of lymphocytes into the brain parenchyma. These results are discussed in terms of the systemic organization of the cells network.
About the Authors
T. N. Sergeyeva
ФГБОУ ВПО «Удмуртский государственный университет» Минобрнауки РФ
Russian Federation
Russian Federation
V. G. Sergeyev
ФГБОУ ВПО «Удмуртский государственный университет» Минобрнауки РФ
Russian Federation
Russian Federation
V. M. Chyuchkov
ФГБОУ ВПО «Удмуртский государственный университет» Минобрнауки РФ
Russian Federation
Russian Federation
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Review
For citations:
Sergeyeva T.N., Sergeyev V.G., Chyuchkov V.M. Cell mechanisms of chronic neuroinflamation. Morphological newsletter. 2014;22(4):26-31. (In Russ.) https://doi.org/10.20340/mv-mn.2014.0(4):26-31
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