THE STUDY OF EMBRYOTOXIC EFFECT OF TITANIUM DIOXIDE NANOPERTICLES ON RATS
https://doi.org/10.20340/mv-mn.17(25).03.37-42
Abstract
The widespread use of nanomaterials in various fields of human activity leads to a number of problems. It is well known that some nanomaterials may have an embryotoxic effect, having a direct effect on the fetus at penetrating through placental barrier. The purpose of this study is to evaluate, on the basis of the study of pre-implantational and post-implantational mortality and features of postnatal development, the embryotoxic properties of nanodispersed titanium dioxide (TiO2) when administered orally. It has been shown that oral administration of 50 mg/kg nanodispersed titanium dioxide to pregnant female rats from the 1st to 19th day of pregnancy has a pronounced embryotoxic effect, expressed in an increase in pre-implantational, post-implantational and total embryonic fetal mortality. The long-term effects of the antenatal effect of nanodispersed titanium dioxide on the development of the offspring of rats in the early postnatal period of ontogenesis were studied in the first 30 days of life. An increase in the death rate of rats during the feeding period, a delay in their weight and a delay in morphological and functional maturation in the postnatal stage of ontogenesis have been established. Thus, in spite of the existence of biological barriers, which in general sufficiently effectively protect the developing organism, the titanium dioxide nanoparticles investigated by us seem to have significant embryotoxic effects, including those delayed in their manifestation in the exposed offspring.
About the Authors
L. A. Sharafutdinova
Bashkir State University
Russian Federation
Russian Federation
Z. R. Khismatullina
Bashkir State University
Russian Federation
Russian Federation
M. R. Daminov
Bashkir State University
Russian Federation
Russian Federation
V. V. Valiullin
Kazan State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Sharafutdinova L.A., Khismatullina Z.R., Daminov M.R., Valiullin V.V. THE STUDY OF EMBRYOTOXIC EFFECT OF TITANIUM DIOXIDE NANOPERTICLES ON RATS. Morphological newsletter. 2017;25(3):37-42. (In Russ.) https://doi.org/10.20340/mv-mn.17(25).03.37-42
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