Despite advances in assisted reproductive technologies, the high failure rate of existing stimulation protocols remains a key industry challenge. One of the leading reasons for this is the limited ability to assess the biological potential of the embryo and its chances of implantation. Over the past ten years, the focus of attention in reproductive technologies has significantly shifted from the patient to the embryo, since the need to improve their effectiveness stimulates the need to understand the deep processes of early development of the embryo. In order to increase the effectiveness of in vitro fertilization procedures in clinical embryology, high-tech methods of culturing and evaluating embryos are being introduced and improved. The purpose of the review is to demonstrate the history, possibilities and prospects in the study of early human embryonic development of time-lapse imaging technology. The active study and use of the capabilities of the time-lapse slow-motion technology allowed not only to expand the understanding of the processes of early development of the embryo, but also at the current moment allows us to assess its potential from the point of view of both biological and clinical perspectives. The main advantages of this method are the possibility of morphological assessment during the continuous cultivation of embryos in closed-type incubators without their extraction, as well as the determination of the exact time intervals of key events of the stages of embryo development with special attention to those moments that are not available for observation and fixation under conditions of traditional cultivation. clinical practice. The main point of growth for the development of time-lapse imaging technology was the creation and validation of the so-called morphokinetic criteria and algorithms for assessing the quality of developing embryos. The key perspective of the method is its use in combination with elements of artificial intelligence in order to predict the most potential embryo for transfer into the uterine cavity. Modern directions of research using the method of time-lapse shooting are the continuation of the development of morphokinetic algorithms and their effective criteria, the introduction of the technology of self-learning computer programs and the adaptation of these tools in clinical practice, the search and assessment of possible factors influencing the morphokinetics of embryos, quality control of the work of embryological laboratories. The future development of such technologies is presented in combination not only with the capabilities of artificial intelligence, but also in combination with the use of non-invasive genetic screening, the assessment of metabolomics and proteomics of developing embryos.

In modern specialized literature, there is practically no information about the shape, size and topography of one of the most important formations of the perineum - of the perineal body. Knowledge of the anatomical aspects of the structure and location of the perineal center would allow in the future to reduce the postoperative complications associated with unintentional damage. The question of the morphology of the perineal body and associated muscles in clinical practice in obstetric traumatism remains relevant. The aim of the study was to study the morphometric parameters and features of the topography of the human perineal body. The objects of the study were 50 autopsy cases of people aged 60-87 years, 25 of each sex, who died from causes not related to the pathology of the pelvic organs. In each case, the perineal body, location of its center and associated muscles were identified. Methods of classical anatomical preparation, description and statistical analysis were used in the work. As a result of the work, five forms of the perineal body were identified: cruciform, «hourglass», triangular, round, polygonal. There were also cases where it was not possible to determine the shape of the intersection of the fibers. For men, the most common triangular shape, for women - the shape of an «hourglass». In most cases in which the shape of the intersection of the fibers was determined, there were clearly identifiable tendon fibers, that is, the tendinal center of the perineal body was present. The average area of ​​the tendinal center of the perineal body in women was 0.99±0.47 cm², and in men 0.94±0.32 cm². The ratio of cases of displacement of the tendinal center towards the right or left ischial tuberosities is almost equal to 10 cases towards the right ischial tuberosity and 11 cases towards the left. When evaluating the pubo-coccygeal asymmetry, in most cases with a triangular shape, there is a sharp displacement towards the apex of the coccyx. Also, the authors found that the average area of ​​the tendinal center of the perineal body is larger in women than in men. Thus, the human perineal body has a variety of forms, according to the authors, associated not only with the embryological features of the development of the muscles of the perineum, but also with the lifestyle, a history of diseases and surgical interventions in the area of ​​the tendinal center of the perineal body.

The aim of the study is a comparative analysis of the linear parameters of the length and width of the diaphysis of the middle phalanges in children and adolescents of Tajikistan and Western India, and also the possibility of using these linear parameters to establish the age of children of the compared ethnic groups. On 325 radiographs of the right hand in male children and adolescents of the Kanibadam region of the Republic of Tajikistan and the city of Mumbai (Western India) at the age of 6-17 years, the length of the middle phalanges and the width of their diaphysis were determined. To determine the relationship between the age of children of the compared ethnic groups and the linear parameters of the length and width of the shaft of the phalanges, Spearman's nonparametric correlation coefficient was used. Comparative assessment of the values ​​of indicators by age was carried out by the method of parametric and non-parametric analysis. In boys of Tajikistan, the closest correlation was established between the age of children and the length of the middle phalanx of the third finger, while in their Indian peers this ratio was determined evenly for the II-IV fingers of the hand. The width of the diaphysis of the phalanges of the fourth finger increased most significantly with age in boys of Tajikistan, and in the Indians, the width of the third finger, the smallest increase in the width of the diaphysis in the compared groups was determined for the phalanges of the second finger. The linear parameters of the middle phalanges of the hand can be used to identify the age of children and adolescents in Tajikistan and Western India at the age of 6-17 years. For Tajik children, the best predictor of age is the linear parameter of the length of the middle phalanx of the index, and for their Indian peers, the length of the middle phalanx of the II-IV fingers is equally.

The study of the age-related anatomical variability, its exact morphological characteristics in adulthood, established using modern research methods, are needed, which can serve as a criterion for a conditional norm. The aim of the study is to determine the macro- and micro-morphometric parameters of the ampulla of the fallopian tubes of women in the first period of adulthood using prosection material and their morphological characteristics. The ampulla of both fallopian tubes of 44 nulliparous and 58 giving birth women of the first period of adulthood (from 21 to 35 years) were examined. Organometric, histological, immunohistochemical and macro- and micro-morphometric research methods were used. It determined the length of the ampoules, their outer diameter at the junction of the isthmus in the ampoule, in the central part of the ampoule and at the junction of the ampoule in the funnel. Histological sections were stained with hematoxylin and eosin, picro fuchsin according to van Gieson. In the immunohistochemical study of the samples, antibodies against vimentin and the CD68 marker were used. The area of ​​the lumen of the ampulla of the fallopian tube and the area of ​​its wall was calculated, and the circumference of the epithelial lining was measured. As a result, it was found that the outer diameter of the fallopian tubes at the junction of the isthmus into the ampulla and the ampoule into the funnel, as well as in the central part of the ampoule, is characterized by the absence of a statistically significant difference in parameters in nulliparous and giving birth women. The histological picture of the ampulla of the fallopian tubes both in nulliparous and in women giving birth in the first period of adulthood is of the same type and is represented by a mucous membrane that forms many thin papillary folds, internal circular and external longitudinal layers of smooth muscle tissue of the muscular membrane and the serous membrane. The detection in the tissues of the ampulla of the fallopian tubes in nulliparous and giving birth women in a moderate amount of CD68-immunopositive macrophages, the concentration of which increases in the epithelium and near it, as well as the expression of vimentin in the vessel walls and individual fibroblasts, indicates the presence of physiological tissue regeneration processes. Analysis of the indicators of the areas of the lumen of the ampoule and its wall at the median section, as well as the circumference of the epithelial lining, allows us to conclude that these parameters predominate in the right fallopian tube.

There are practically no data on the quantitative aspects of prenatal morphogenesis and the growth rates of the ligaments of the hip joint in humans, as well as information on the correspondence of the shape and structure of the ligaments to the bones forming the joint. The aim of the study was to reveal the features of the growth of the extra-articular ligaments of the hip joint in the prenatal period and to establish correlations between the structure of the ligaments and the structures of the proximal end of the femur. The material of the study is based on the analysis of 175 cases without pathology of the musculoskeletal system. The dimensions of the ilio-femoral, pubic-femoral, ischio-femoral ligaments and the cervico-diaphyseal angle and angle of rotation of the femoral neck in relation to the distal epiphysis of the bone were studied. As a result of the study, it was found that in the process of prenatal development with increasing age, the distance between the distal fixation points and the angle between the parts of the ilio-femoral ligament increases. Both legs have fibers that are woven into the fibrous membrane of the joint capsule. A correlation was found between the growth of morphometric parameters of the ilio-femoral ligament and the angular values ​​of the proximal femur. In contrast to the ilio-femoral ligament, the pubo-femoral and ischio-femoral ligaments show low signs of differentiation at different stages of prenatal ontogenesis. The pubo-femoral ligament becomes available for macroscopic examination from the beginning of the second half of the prenatal period. It is defined as a thickening of the medial fibrous membrane of the joint capsule, has its origin on the superior branch of the pubic bone and the iliac part of the acetabulum and is attached to the intertrochanteric line in the medial segment. The sciatic-femoral ligament is macroscopically defined as a thickening of the posterior part of the joint capsule. The ligament has a triangular shape, with a base in the region of the ischial part of the acetabulum and the ischial tubercle, its apex facing the trochanteric fossa at the antero-inner edge of the greater trochanter. It was found that the growth rate of morphometric parameters of different parts of the hip joint ligaments at different stages is not the same, which determines the change in the shape of the ligaments. The greatest transformations occur in the ilio-femoral ligament, the smallest in the pubic-femoral and sciatic-femoral ligaments. There is a correlation between the anatomical structure of the extra-articular ligaments of the hip joint and the corresponding angular values ​​of the proximal femur.

Myocardial (muscle) bridges are considered a variant of the normal anatomy of the coronary arteries, but there are some reports of their clinical significance: their presence is associated with angina pectoris, myocardial infarction, ventricular tachycardia, and sudden cardiac death. In this study, using a clinical case as an example, the significance of the problem, approaches to assessing perioperative risk and methods for identifying risk factors at the preoperative stage in a patient with abnormal coronary arteries are presented. At stydiyng clinical case according to the results of coronary angiography in the 7th segment of the anterior interventricular artery, a myocardial bridge with stenosis in systole up to 95% was revealed, which, against the background of hemorrhagic shock, could provoke the development of acute coronary syndrome. An analysis of a clinical case, a review of the literature on assessing the risks of patients with myocardial bridges demonstrates an insufficient assessment of this morphological feature for patients with a non-cardiac surgery profile. In the studied case, the patient underwent elective orthopedic surgery and emergency surgery aimed at stopping bleeding. Surgery with concomitant trauma, systemic inflammatory response, anesthesia and analgesia, pain, hypothermia, bleeding, anemia, and nutritional deficiencies is similar to an extreme stress test. The combination of these factors provokes inflammatory, hypercoagulable, stressful and hypoxic conditions, which are associated with a perioperative increase in troponin levels, arterial thrombosis and, as a consequence, a high risk of mortality. The authors suggest that current clinical guidelines for assessing perioperative risks need to be improved. With such a refinement, it is necessary to rely not only on the existing international recommendations, but also on the results of the latest meta-analyzes devoted to the prognostic role of preventive myocardial recanalization before surgery. Thus, in summary, it can be noted that the existing clinical guidelines and risk assessment scales do not contain ready-made solutions for all clinical cases, but can only be the basis for making decisions in specific situations and do not provide sufficient guarantees of the success of surgical interventions.

One of the tasks of science of the constitution, along with the definition of a human's somatotype, is to identify the characteristic typological features of a body region, morphological and functional system or an individual organ, which, in combination with new morphological and clinical research methods, is of great scientific and practical importance. Interest in morphological and functional studies of the thyroid gland has been steadily growing over the past thirty years, which is associated with an increase in oncological diseases of this organ in young women and is caused by the deterioration of the environment and radiation pollution of the environment as a result of technological disasters. In addition, the development of iodine-deficient conditions increases, which affect the function of the thyroid gland. The purpose of the review is a descriptive meta-analysis of modern scientific data on the structure of the thyroid gland depending on the parameters of the neck and constitutional and typological characteristics of women. It was found that despite the large number of publications devoted to the morphology of the thyroid gland, most of the parameters of this organ were obtained only by standard ultrasound examination; insufficiently studied tissue organization of the gland at the macro-microscopic level; there is no unified classification of forms of the thyroid gland and data on the distribution of their frequency in persons of different sex; the relationship of the anatomical characteristics of this organ with the size of the neck, as well as with the somatotype, has not been sufficiently studied. It is noted that the majority of authors who carry out somatotyping prefer one scheme of constitutional diagnostics and rarely use a set of methods. Obviously, due to the increase in the incidence of the thyroid gland in young people, the objects of research should be people of young age. The increase in the frequency of oncological diseases of the thyroid gland and the success of endocrine surgery require a new approach to patients and dictate the need for a comprehensive study of this organ, taking into account the local and general constitution in women of a mature age period. Until now, researchers do not have an exact answer to the question of what constitutionally determined features can be identified in the neck area and whether there is a connection between the main morphological parameters of the thyroid gland with the somatotype and physical development of a person. Comprehensive studies of the thyroid gland, taking into account the parameters of the neck and constitutional variability of a person, may have new theoretical and practical significance.

Hypothyroidism is a systemic chronic disease that occurs as a result of a deficiency of thyroid hormones (thyroid hormones): triiodothyronine and tetraiodothyronine (thyroxine). Targets of thyroid hormones are almost all organs and tissues of the human body, which explains the variety of clinical manifestations that occur when these hormones are deficient. Recently, basic research through the use of experimental models has become more relevant and allowed us to obtain a number of new morphological and functional changes that occur in hypothyroidism. This review discusses the main experimental models of hypothyroidism: surgical, radioactive, dietary, anti-thyroid administration and genetics’ model. The main principle of the surgical model of hypothyroidism is to remove the thyroid gland. The radioactive model is based on the introduction of a radioactive isotope of iodine to laboratory animals. The dietary model is based on the use of a special diet with a limited amount of iodine. The drug model is based on the introduction of antithyroid drugs - methylimidazole and propylthiouracil. The principle of the genetic model consists in special genetic manipulations with the genome of laboratory animals. The advantages and disadvantages of each model are discussed. The use of sophisticated equipment has brought specialists closer to a more complete and holistic understanding of the morphological and functional manifestations of hypothyroidism. Researching of experimental models is an important tool in relation to the studying of the mechanisms underlying hypothyroidism and, as a result, in improving prevention and treatment-diagnostic strategies.

In general, the reviewed work is one of the best textbooks on the discipline of (human) anatomy, not only in the Russian Federation, but also in some CIS countries, in which it is actively used in the educational process and received of positive responses. It is in demand not only by students, but also by medical practitioners. It should be emphasized once again that this is a thoroughly revised, supplemented reissue. It retains the traditional form and method of presenting the material, familiar to many generations of former students, and now doctors, focuses on the heading of sections, supplemented the illustrative series, created summarizing tables on blood supply and innervation, highlighted the most important information necessary for the subsequent study of clinical disciplines. All changes and additions made by the author will facilitate preparation for the exam and are very important for subsequent practice. The main advantage of the reviewed textbook is the originality of the presentation of the material. The author managed to comply with the modern requirements of state educational standards of the third generation and in an accessible form to present the material, which is the basis for the subsequent study of a number of theoretical and all clinical disciplines. The information presented is accurate, reliable and scientifically proven, anatomical terms are given in accordance with the international anatomical nomenclature TA-1 (1999). In such a large work, some inaccuracies and typos cannot be avoided; some classifications proposed in the textbook are controversial. The point of view presented by the author is traditional for the morphological school of the Military Medical Academy, it is supported by a number of prominent anatomists and has a right to exist.