Traumatic injuries and fractures of the lower jaw are an urgent problem in maxillofacial surgery and traumatology. The strength of the bone tissue of the lower jaw has been studied on 90 lower jaws of adults. All jaws are systematized into three groups: with intact bite, partial and complete loss of teeth. To assess the architectonics of the bone tissue of the mandibular body, sagittal and frontal cuts were made in the molar region. It has been established that, in the case of a complete set of teeth, the ultimate strength of the bone tissue in the area of the incisors is 441.3 ± 32 MPa; in the area of premolars 411.9 ± 20 MPa; molars 431.3 ± 24 MPa; in the area of the base of the coronoid process 156.9 ± 14 MPa; in the area of the base of the condylar process 205.9 ± 19 MPa. To the greatest extent, with partial loss of teeth, the strength of bone tissue in the region of the molars and the angle of the lower jaw changes in Kennedy classes I and II. With the complete loss of teeth, the values of bone strength in the area of molars, angle and condylar process decreased by 22.5-27.7%, in the area of incisors by 6.7%. It was shown that with a full set of teeth, class II according to U. Lekholm and G. Zarb was most often observed - in 66.7% of cases, less often class I - in 16.7% and class III - in 13.3%, class IV was observed most rarely - in 3.3% of cases. With complete loss of teeth, the presence of mainly II and III classes is noted. It has been proven that the strength of the bone tissue of the lower jaw body decreases significantly with age with the loss of teeth in an adult, which is associated with significant changes in the quality of bone tissue.

Prolonged use of immunosuppressants with a selective mechanism of action is a promising strategy in the prevention of postoperative scarring in glaucoma surgery. In order to assess the cellular response of eye tissues to the implantation of bioresorbable drains saturated with cyclosporin A or everolimus, a filter-type hypotensive operation with implantation of polylactide-based drains was simulated in 12 rabbits. Drainages implanted in rabbits of the two experimental groups under study were pre-saturated with either cyclosporin A or everolimus. The control group consisted of animals that were implanted with drains not saturated with any drugs. On the 7th day after the operation, the animals were taken out of the experiment, the eyeballs were enucleated, and histological preparations stained with hematoxylin and eosin, as well as hematoxylin and Picrosirius-red were prepared. Using a score on a scale from 0 to 5, the cellular composition within the drainage material, the intensity of collagen synthesis in the drainage, the thickness of the capsule around the drainage, and the number of blood vessels were analyzed. In comparison with the control group, the study groups showed a significantly lower amount of mononuclear cells, fibroblasts and giant cells of foreign bodies, as well as a lower thickness of the capsules surrounding the drainage, up to their complete absence. In addition, the intensity of collagen synthesis inside the drainage material of the studied groups was significantly lower. The drains of the everolimus group were characterized by an extremely low density of viable cellular elements inside the implanted material and a complete absence of collagen. At the same time, no toxic effect of the substance on the surrounding tissues was found. Thus, the saturation of bioresorbable drainages based on polylactide with cyclosporin A and everolimus contributed to a decrease in the intensity of the formation of connective tissue elements both inside and around the drainage in the early postoperative period.

The use of video-endoscopic equipment in pediatric rhino-surgery necessitates a thorough study of the structure of the nasal cavity structures at different age periods. The aim of the study was to study the width of the nasal meatuses in childhood based on craniometrics data. Craniometry of 65 children's skulls was performed, divided into six groups (infancy, early childhood, first and second childhood, adolescence and youth). It was found that the width of the nasal meatuses increases unevenly with the age of the child; periods of the permanency are replaced by periods of growth. The maximum values of the width of the lower and middle nasal meatuses of the skull reach in adolescence, and the general meatuses - in adolescence. Also, an increase in the width of the middle and common nasal meatuses was revealed along their length from the anterior to posterior edges of the nasal conches by an average of 30%, while the width of the lower nasal meatuses remains constant. The ratios of the width of the lower and middle nasal meatuses to the width of the common nasal passages were determined depending on age. The width of the inferior nasal meatus to the width of the common nasal meatus at 1-1.5 years is 1: 2 at the level of the anterior end of the inferior nasal conchae and 1: 3 at the level of its posterior end, in other age groups it is 1: 1.5 and 1: 2 respectively. The width of the middle nasal meatus to the width of the common nasal meatus at the level of both ends of the middle meatus in each age group is 1: 1. The obtained data are of clinical importance for the choice of trans-nasal surgical access, for the choice of the size of endoscopic instruments, the diameter and angle of view of endoscopes, the preservation of age-related physiological relationships of the structures of the nasal cavity, and the reduction of the risk of intraoperative complications. Up to 4 years old, it is recommended to use endoscopes and endoscopic instruments of the smallest diameter; over 4 years old, the size of the nasal passages makes it possible to increase the diameter of the endoscopic set to improve access.

Students belong to a group of high health risks, since during this period of development, young people are under the influence of the inevitable processes of active physiological restructuring of the body and intensive socialization of the individual. The purpose of the study is the anthropometric indicators and indices of physical development of 1648 girls aged 17-21 of the Republic Mordovia. Anthropometric measurements included the determination of the following parameters: body weight, standing and sitting body length, circumference of the chest, shoulder, forearm, wrist, thigh, abdomen, buttocks, lower leg, ankles. The comprehensive research program was designed in such a way that it was possible to calculate body surface areas, weight and height values, body strength indices and body proportionality indices. It was found that in the studied population, girls have a wide face, a narrow long nose, and a medium-sized skull. The majority of the population is characterized by the absence of excess body weight. Girls have a normosthenic type of constitution, have an average level of physical development, an average level of body density. Among female students, a mesomorphic type of physique is common with proportional body development, a normal proportion of the bone component and a slightly increased proportion of fat and muscle components. The inversion and dysplasia of sexual dimorphism revealed in the course of the study may be a response of a more labile female body to the negative influences of social and environmental factors.

After the creation of a method for obtaining inter-neuronal gap junctions in a nervous system devoid of glia, it is expedient to reproduce gap neuronal-glial contacts on a model that also contains hybrid neuronal-glial gap junctions, which, as you know, are functionally fundamentally different from inter-neuronal contacts. The experiments were carried out on the truncus sympathicus ganglia of laboratory rats using pessimal electrical stimulation and transmission electron microscopy. Electrical activation of ganglia with a frequency of up to 100 Hz revealed local and widespread variants of various neuronal-glial connections (contacts, bridges), fringed with peri-membrane filamentous proteins. They had a blurred veil that masked two-layer neuro-membranes. Some of the contacts resembled slit or dense 5-layer structures without a visible inter-neuronal slit, but with an extreme decrease in the thickness of the contact slit. The main result of the experiments was the formation, in addition to slotted, multiple septate (ladder) contacts. Relatively independent aggregates of the electron-dense substance of the septa were located inside the intercellular gaps, crossing both adjacent membranes, and, possibly, permeate of them. Near-membrane, poorly outlined pyramid-like protein cones associated with both cell membranes were also formed. Such membranes appeared to be dotted-dashed, that is, not continuous. A significant number of septic contact membranes had endocytic invaginations (invaginations) facing neuroplasm with pyramid-like marginal projections. All reactive altered structures that have arisen de novo are considered by the authors as developed under the influence of frequency electrical stimulation of denaturation and aggregation of intrinsic and perimembrane proteins.

As a result of the introduction of imaging research methods into clinical practice, the frequency of detection of cavities in the liver has significantly increased, among which nonparasitic cysts have not been sufficiently studied. The paper provides an overview of the most commonly used classifications of this pathology. Clinical and radiological manifestations of cysts were investigated based on the analysis of the results of computed tomography, magnetic resonance imaging and ultrasound sonography of 175 patients (109 with solitary cysts and 66 with polycystic liver). The tissues of the resected areas of 81 cysts and adjacent liver tissue were studied by histological and immune-histochemical methods. Various variants of liver cysts were identified: polycystic cysts, solitary cysts and the rarest variant - ciliated anterior-intestinal hepatic cysts. The morphological and histogenetic features of solitary and ciliated anterior-intestinal hepatic cysts, as well as changes in the liver tissue adjacent to the cavities, are described. Polycystic is characterized by the presence of cavities of various sizes, with thin connective tissue partitions and a lining of cubic or flattened epithelium. The lining of solitary cysts is represented by cubic, cylindrical, sometimes multi-row epithelium. Immature biliary structures in the form of von Meijenburg complexes, islets of hepatocytes, conglomerates of dysplastic vessels are revealed in their wall among the cells of connective tissue. Ciliated anterior-intestinal hepatic cysts contain components of the primary intestine wall - a lining of a cylindrical ciliated epithelium, a layer of loose connective tissue, a muscle layer, a connective tissue capsule. Morphological studies made it possible to establish violations of embryogenesis in various types of cysts. Ciliated anterior intestinal hepatic cysts develop from the anterior section of the primary intestine, while solitary cysts are derived from its middle section. Migration of the developing buds of bronchioles from the cranial part of the primary midgut into the hepatic diverticulum determines the presence of all components of the wall of the hollow organ - cylindrical ciliated epithelium, loose connective tissue, bundles of smooth muscle fibers. Simple solitary cysts are the result of abnormal remodeling of the embryonic ductal lamina, thus being a developmental abnormality of the middle section of the primary midgut. Morphological examination of the liver tissue adjacent to the walls of the cysts reveals hypoplasia of lobules, persistence of elements of the embryonic ductal plate in the form of cords and complexes of the biliary epithelium, foci of ductopenia, von Meijenburg complexes, and various variants of vascular dysplasia.

The actuality of the problem is associated with an increase in the number of patients with cholelithiasis of working age and a significant increase in cholecystectomies not only in Russia, but throughout the world. It is known that more than 2,5 million are performed annually. Moreover, 5-40% of operated patients develop postcholecystectomy syndrome, which is manifested by recurrent abdominal pain and cholegenic diarrhea. The aim of the study is to assess morphofunctional changes in the mucous membrane of various parts of the intestine in patients with postcholecystectomy syndrome. Histological, histochemical, morphometric and bacterioscopic, parasitological methods were used to study 42 biopsy specimens of the mucous membrane of various parts of the intestines of patients who underwent cholecystectomy. The control group consisted of 18 biopsies of practically healthy individuals. To objectify the study, a morphometric study of the mucous membrane of the duodenum according to 34 parameters, of the cecum and sigmoid colon according to 22 parameters was carried out. In the mucous membrane of the duodenum, chronic duodenitis of varying degrees of activity of the pathological process and atrophy of the intestinal villi were revealed, the intestinal glands were shortened, the intestinal villi are less wide. The epithelial layer of intestinal villi and intestinal glands was abundantly infiltrated with neutrophilic granulocytes. The density of the inflammatory cellular infiltrate in the stroma of the intestinal villi and intestinal glands increased. On the surface of the epithelial layer of the intestinal villi and between the intestinal glands, campylobacters were often found, less often - cryptosporidia. In the mucous membrane of the cecum and sigmoid colon, chronic colitis of varying degrees of activity of the pathological process and atrophy of the intestinal glands were revealed. The thickness of the mucous membrane and the depth of the intestinal glands were lower than normal. Thus, in patients with postcholecystectomy syndrome, pronounced morphometric and histological changes were revealed in the mucous membrane of various parts of the intestine, while the depth and degree of its damage were more significant in its proximal parts.

The Republic of Sakha (Yakutia) belongs to the regions with significant iodine deficiency in nature and is characterized by a high prevalence of thyroid pathology among children and adults. Due to the fact that the diagnosis of thyroid pathology is associated primarily with ultrasound examination, the deepening of information about the regional features of the absolute and relative indices of the anatomical norm of the thyroid gland is a rather urgent scientific task. The aim of the study was to study the normal ultrasound anatomy of the thyroid gland in young men and women of indigenous nationality living in the Republic of Sakha (Yakutia). The authors carried out an ultrasound examination of 110 students (including 66 girls and 44 boys) of the indigenous nationality, aged 17 to 21 years. Sexual dimorphism of the thyroid gland volumes of the indigenous population of the Sakha Republic (Yakutia) was established. The minimum, maximum and average values of the thyroid gland volume in boys are higher than in girls. The shape of the lobes of the thyroid gland in girls and boys of the indigenous population in most cases is close to a regular ellipsoid. The most common form of a regular ellipsoid is in 53.8% of cases in girls and 46,4% of cases in boys. The shape of an ellipsoid flattened in the frontal plane was visualized to a greater extent in boys (35,4%) and in 29,6% of girls, an ellipsoid flattened in the sagittal plane was determined to a lesser extent, in 3,8% and 4,1% cases, respectively. Thus, the quantitative characteristics of the thyroid gland obtained as a result of the study made it possible to reveal the features of the vital anatomy of this organ, variable in its anatomy, in the indigenous population of the Republic of Sakha (Yakutia), depending of the sex. The obtained results have territorial referential significance.

The article describes the history of the Department of Human Anatomy at Omsk State Medical University. At the stages of its formation, the continuity, preservation and enhancement of the traditions of the Russian anatomical school are traced. It is noted that in the training of doctors, the staff of the department adheres to a reasonable combination of traditional anatomical methods with innovations and modernization of the educational process. Brief biographies, scientific and pedagogical staffs of the heads of the department are presented and the team of teachers at each stage during the centuries-old history is characterized. In teaching of students, the department implements onto- and phylogenetic principles, a functional approach, the doctrine of individual variability, and the clinical orientation of teaching. The main scientific areas of research of the department staff are the study of individual, age-related topographic and projection features of organs and other anatomical structures on the skeleton and skin of the human body, experimental and clinical lymphology and angiology, and the development of the museum.                                                                                                                          

                                                                                                                                                

                                                                                                                                                

                                                                                                                                                 

Anniversary article - without summary